ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Cortical inhibition reduces information redundancy at presentation of communication sounds in the primary auditory cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- GABAergic neurons in basal forebrain exert frequency-specific modulation on auditory cortex and enhance attentional selection of auditory stimuli.Communications biology · 2025Article
- Article
- Connectivity Analysis in EEG Data: A Tutorial Review of the State of the Art and Emerging Trends.Bioengineering (Basel, Switzerland) · 2023Review
- Age-related changes in excitatory and inhibitory intra-cortical circuits in auditory cortex of C57Bl/6 mice.Hearing research · 2023Article
- Updates to the guinea pig animal model for in-vivo auditory neuroscience in the low-frequency hearing range.Hearing research · 2022Article
- Exposure to 1800 MHz LTE electromagnetic fields under proinflammatory conditions decreases the response strength and increases the acoustic threshold of auditory cortical neurons.Scientific reports · 2022Article
- Increased Threshold and Reduced Firing Rate of Auditory Cortex Neurons after Cochlear Implant Insertion.Brain sciences · 2022Article
- Distinct timescales for the neuronal encoding of vocal signals in a high-order auditory area.Scientific reports · 2021Article
- Neuronal selectivity to complex vocalization features emerges in the superficial layers of primary auditory cortex.PLoS biology · 2021Article
- Noise-Sensitive But More Precise Subcortical Representations Coexist with Robust Cortical Encoding of Natural Vocalizations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neuronal Encoding in a High-Level Auditory Area: From Sequential Order of Elements to Grammatical Structure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Age-related Changes in Neural Coding of Envelope Cues: Peripheral Declines and Central Compensation.Neuroscience · 2019Review
- Subcortical pathways: Towards a better understanding of auditory disorders.Hearing research · 2018Review
- Robust Neuronal Discrimination in Primary Auditory Cortex Despite Degradations of Spectro-temporal Acoustic Details: Comparison Between Guinea Pigs with Normal Hearing and Mild Age-Related Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Article
- Neuroplasticity: Insights from Patients Harboring Gliomas.Neural plasticity · 2016Review
- High Stimulus-Related Information in Barrel Cortex Inhibitory Interneurons.PLoS computational biology · 2015Article
- Stimulus-specific effects of noradrenaline in auditory cortex: implications for the discrimination of communication sounds.The Journal of physiology · 2015Article
- Recognition of Modified Conditioning Sounds by Competitively Trained Guinea Pigs.Frontiers in behavioral neuroscience · 2015Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
In all sensory modalities, intracortical inhibition shapes the functional properties of cortical neurons but also influences the responses to natural stimuli. Studies performed in various species have revealed that auditory cortex neurons respond to conspecific vocalizations by temporal spike patterns displaying a high trial-to-trial reliability, which might result from precise timing between excitation and inhibition. Studying the guinea pig auditory cortex, we show that partial blockage of GABAA receptors by gabazine (GBZ) application (10 μm, a concentration that promotes expansion of cortical receptive fields) increased the evoked firing rate and the spike-timing reliability during presentation of communication sounds (conspecific and heterospecific vocalizations), whereas GABAB receptor antagonists [10 μm saclofen; 10-50 μm CGP55845 (p-3-aminopropyl-p-diethoxymethyl phosphoric acid)] had nonsignificant effects. Computing mutual information (MI) from the responses to vocalizations using either the evoked firing rate or the temporal spike patterns revealed that GBZ application increased the MI derived from the activity of single cortical site but did not change the MI derived from population activity. In addition, quantification of information redundancy showed that GBZ significantly increased redundancy at the population level. This result suggests that a potential role of intracortical inhibition is to reduce information redundancy during the processing of natural stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.