ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Concurrent maturation of inner hair cell synaptic Ca2+ influx and auditory nerve spontaneous activity around hearing onset in mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Review
- Gating of hair cell CaScience advances · 2025Article
- Article
- Article
- Priming central sound processing circuits through induction of spontaneous activity in the cochlea before hearing onset.Trends in neurosciences · 2024Review
- Female GluA3-KO mice show early onset hearing loss and afferent swellings in ambient sound levels.bioRxiv : the preprint server for biology · 2024Article
- Diversity matters - extending sound intensity coding by inner hair cells via heterogeneous synapses.The EMBO journal · 2023Review
- Loss of central mineralocorticoid or glucocorticoid receptors impacts auditory nerve processing in the cochlea.iScience · 2022Article
- The CleLife · 2022Article
- Analog transmission of action potential fine structure in spiral ganglion axons.Journal of neurophysiology · 2021Article
- Synaptic Contributions to Cochlear Outer Hair Cell CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Encoding sound in the cochlea: from receptor potential to afferent discharge.The Journal of physiology · 2021Review
- A sensory cell diversifies its output by varying CaThe EMBO journal · 2021Article
- Purinergic Modulation of Activity in the Developing Auditory Pathway.Neuroscience bulletin · 2020Review
- Phase Locking of Auditory Nerve Fibers: The Role of Lowpass Filtering by Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Functional Development of Principal Neurons in the Anteroventral Cochlear Nucleus Extends Beyond Hearing Onset.Frontiers in cellular neuroscience · 2019Article
- Decreased levels of superoxide dismutase in inner pillar cells contribute to ribbon synapse impairment in presbycusis.American journal of translational research · 2019Article
- Differential Expression of CaExperimental neurobiology · 2018Article
- Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.Physiological reviews · 2018Review
- Voltage-Gated Calcium Influx Modifies Cholinergic Inhibition of Inner Hair Cells in the Immature Rat Cochlea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hearing over a wide range of sound intensities is thought to require complementary coding by functionally diverse spiral ganglion neurons (SGNs), each changing activity only over a subrange. The foundations of SGN diversity are not well understood but likely include differences among their inputs: the presynaptic active zones (AZs) of inner hair cells (IHCs). Here we studied one candidate mechanism for causing SGN diversity-heterogeneity of Ca(2+) influx among the AZs of IHCs-during postnatal development of the mouse cochlea. Ca(2+) imaging revealed a change from regenerative to graded synaptic Ca(2+) signaling after the onset of hearing, when in vivo SGN spike timing changed from patterned to Poissonian. Furthermore, we detected the concurrent emergence of stronger synaptic Ca(2+) signals in IHCs and higher spontaneous spike rates in SGNs. The strengthening of Ca(2+) signaling at a subset of AZs primarily reflected a gain of Ca(2+) channels. We hypothesize that the number of Ca(2+) channels at each IHC AZ critically determines the firing properties of its corresponding SGN and propose that AZ heterogeneity enables IHCs to decompose auditory information into functionally diverse SGNs.
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