ArticleEpigenetics2013
Association between hypermethylation of DNA repetitive elements in white blood cell DNA and early-onset colorectal cancer.
Article in Epigenetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Quantitative methylation level of the EPHX1 promoter in peripheral blood DNA is associated with polycystic ovary syndrome.PloS one · 2014Trial
- Article
- Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating Occurrence.Cellular and molecular gastroenterology and hepatology · 2025Review
- Unveiling the genetic and epigenetic landscape of colorectal cancer: new insights into pathogenic pathways.Medical oncology (Northwood, London, England) · 2023Review
- Molecular genetics of early-onset colorectal cancer.World journal of biological chemistry · 2023Review
- Inhibitory immune checkpoints PDCD-1 and LAG-3 hypermethylation may reduce the risk of colorectal cancer.Molecular medicine (Cambridge, Mass.) · 2021Article
- Young-onset colorectal cancer: A review.World journal of gastrointestinal oncology · 2021Review
- Article
- Standardization of DNA amount for bisulfite conversion for analyzing the methylation status of LINE-1 in lung cancer.PloS one · 2021Article
- A panel of DNA methylation signature from peripheral blood may predict colorectal cancer susceptibility.BMC cancer · 2020Article
- CHST7 Gene Methylation and Sex-Specific Effects on Colorectal Cancer Risk.Digestive diseases and sciences · 2019Article
- Different EPHX1 methylation levels in promoter area between carbamazepine-resistant epilepsy group and carbamazepine-sensitive epilepsy group in Chinese population.BMC neurology · 2019Article
- Repetitive Element DNA Methylation is Associated with Menopausal Age.Aging and disease · 2018Article
- Article
- Multiple gene-specific DNA methylation in blood leukocytes and colorectal cancer risk: a case-control study in China.Oncotarget · 2017Article
- LINE-1 hypermethylation in white blood cell DNA is associated with high-grade cervical intraepithelial neoplasia.BMC cancer · 2017Article
- Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFNbeta treatment.Scientific reports · 2017Article
- Epigenetics of colorectal cancer: emerging circulating diagnostic and prognostic biomarkers.Annals of translational medicine · 2017Review
- Acceleration of leukocytes' epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer.Oncotarget · 2017Article
- Promoter hypermethylation ofInternational journal of clinical and experimental pathology · 2017Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Changes in the methylation levels of DNA from white blood cells (WBCs) are putatively associated with an elevated risk for several cancers. The aim of this study was to investigate the association between colorectal cancer (CRC) and the methylation status of three DNA repetitive elements in DNA from peripheral blood. WBC DNA from 539 CRC cases diagnosed before 60 years of age and 242 sex and age frequency-matched healthy controls from the Australasian Colorectal Cancer Family Registry were assessed for methylation across DNA repetitive elements Alu, LINE-1 and Sat2 using MethyLight. The percentage of methylated reference (PMR) of cases and controls was calculated for each marker. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression adjusted for potential confounders. CRC cases demonstrated a significantly higher median PMR for LINE-1 (p < 0.001), Sat2 (p < 0.001) and Alu repeats (p = 0.02) when compared with controls. For each of the DNA repetitive elements, individuals with PMR values in the highest quartile were significantly more likely to have CRC compared with those in the lowest quartile (LINE-1 OR = 2.34, 95%CI = 1.48-3.70; p < 0.001, Alu OR = 1.83, 95%CI = 1.17-2.86; p = 0.01, Sat2 OR = 1.72, 95%CI = 1.10-2.71; p = 0.02). When comparing the OR for the PMR of each marker across subgroups of CRC, only the Alu marker showed a significant difference in the 5-fluoruracil treated and nodal involvement subgroups (both p = 0.002). This association between increasing methylation levels of three DNA repetitive elements in WBC DNA and early-onset CRC is novel and may represent a potential epigenetic biomarker for early CRC detection.
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