ArticleJournal of clinical pathology1990
Sialic acid histochemistry and the adenoma-carcinoma sequence in colorectum.
Article in Journal of clinical pathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 24 citations in OpenAlex.
- Eukaryotic protein glycosylation: a primer for histochemists and cell biologists.Histochemistry and cell biology · 2017Review
- Biological similarities and differences between pancreatic intraepithelial neoplasias and intraductal papillary mucinous neoplasms.International journal of gastrointestinal cancer · 2005Article
- Reduction of sialic acid O-acetylation in human colonic mucins in the adenoma-carcinoma sequence.Glycoconjugate journal · 1999Article
- Distribution of O-acetylated sialomucin in the normal and diseased gastrointestinal tract shown by a new monoclonal antibody.Journal of clinical pathology · 1993Article
- The adenoma-carcinoma sequence in the colorectum--early appearance of a hierarchy of small intestinal mucin antigen (SIMA) epitopes and correlation with malignant potential.British journal of cancer · 1992Article
- Altered mucin expression in the gastrointestinal tract: a review.Journal of cellular and molecular medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A change in sialic acid, notably loss of O acetyl substitution, was studied histochemically in a series of 93 colorectal adenomas that included 14 malignant polyps. Changes in sialic acid were uncommon in adenomas showing mild dysplasia but became increasingly common in moderately and severely dysplastic adenomas and were always present in carcinomatous areas. There was no correlation between a change in sialic acid and either size or villous architecture of benign adenomas. As mucin change often preceded the development of invasive cancer, it could not be used on its own to distinguish between epithelial displacement (pseudoinvasion) and malignant invasion. An abundant luminal accumulation of altered sialic acid in association with an epithelial lining that was non-mucin secreting, however, was specific for cancer. Conversely, the presence of unchanged intracellular or intraluminal O-acetyl sialic acid may help to exclude a diagnosis of malignancy in equivocal cases. The change is not specific for colorectal neoplasms and probably represents a metaplasia to a small intestinal phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.