ArticleCerebral cortex (New York, N.Y. : 1991)2014
Characterization and distribution of Reelin-positive interneuron subtypes in the rat barrel cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 44 citations in OpenAlex.
- Reelin Deficiency and Synaptic Impairment in the Adolescent Prefrontal Cortex Following Initial Synthetic Cannabinoid Exposure.Biological psychiatry global open science · 2025Article
- Reelin differentially shapes dendrite morphology of medial entorhinal cortical ocean and island cells.Development (Cambridge, England) · 2024Article
- Reelin Regulates Developmental Desynchronization Transition of Neocortical Network Activity.Biomolecules · 2024Article
- Genetic approaches to elucidating cortical and hippocampal GABAergic interneuron diversity.Frontiers in cellular neuroscience · 2024Review
- Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models.Scientific reports · 2023Article
- Extracellular molecular signals shaping dendrite architecture during brain development.Frontiers in cell and developmental biology · 2023Review
- Differential expression of GABAFrontiers in cellular neuroscience · 2023Article
- Specific contribution of Reelin expressed by Cajal-Retzius cells or GABAergic interneurons to cortical lamination.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Identification of adult spinal Shox2 neuronal subpopulations based on unbiased computational clustering of electrophysiological properties.Frontiers in neural circuits · 2022Article
- Reelin restricts dendritic growth of interneurons in the neocortex.Development (Cambridge, England) · 2021Article
- Development, Diversity, and Death of MGE-Derived Cortical Interneurons.International journal of molecular sciences · 2021Review
- Comparison of Acute Effects of Neurotoxic Compounds on Network Activity in Human and Rodent Neural Cultures.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Distinct Transcriptomic Profiles in the Dorsal Hippocampus and Prelimbic Cortex Are Transiently Regulated following Episodic Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Reelin signaling modulates GABAJournal of neurochemistry · 2021Article
- Increased Callosal Connectivity in Reeler Mice Revealed by Brain-Wide Input Mapping of VIP Neurons in Barrel Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats.Scientific reports · 2021Article
- Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus But Leaves Cortical Layering and Behavior Unaffected.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons.Molecular metabolism · 2019Article
- Distribution Patterns of Three Molecularly Defined Classes of GABAergic Neurons Across Columnar Compartments in Mouse Barrel Cortex.Frontiers in neuroanatomy · 2019Article
- Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer's disease.eLife · 2018Article
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
Abstract
GABAergic inhibitory interneurons (IN) represent a heterogeneous population with different electrophysiological, morphological, and molecular properties. The correct balance between interneuronal subtypes is important for brain function and is impaired in several neurological and psychiatric disorders. Here we show the data of 123 molecularly and electrophysiologically characterized neurons of juvenile rat barrel cortex acute slices, 48 of which expressed Reelin (Reln). Reln mRNA was exclusively detected in Gad65/67-positive cells but was found in interneuronal subtypes in different proportions: all cells of the adapting-Somatostatin (SST) cluster expressed Reln, whereas 63% of the adapting-neuropeptide Y (NPY, 50% of the fast-spiking Parvalbumin (PVALB), and 27% of the adapting/bursting-Vasoactive Intestinal Peptide (VIP) cluster were Reln-positive. Silhouette analysis revealed a high impact of the parameter Reln on cluster quality. By analyzing the co-localization of RELN immunoreactivity with those of different IN-markers, we found that RELN is produced layer-independently in SST-, NPY-, and NOS1-expressing INs, whereas co-localization of RELN and VIP was mostly absent. Of note, RELN co-localized with PVALB, predominantly in INs of layers IV/V (>30%). Our findings emphasize RELN's role as an important IN-marker protein and provide a basis for the functional characterization of Reln-expressing INs and its role in the regulation of inhibitory IN networks.
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