Evidence map›Paper›PMID 23803966›Full record

ArticleNature communications2013

Realistic control of network dynamics.

Sean P Cornelius, William L Kath, Adilson E Motter

Abstract read
In one paragraph

Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed.

  1. Article
  2. A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Cell reprogramming design by transfer learning of functional transcriptional networks.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Resonant learning in scale-free networks.PLoS computational biology · 2023
    Article
  12. Review
  13. Prevalence and scalable control of localized networks.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. NETISCE: a network-based tool for cell fate reprogramming.NPJ systems biology and applications · 2022
    Article
  15. Article
  16. Functional observability and target state estimation in large-scale networks.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Review
  18. Informational architecture across non-living and living collectives.Theory in biosciences = Theorie in den Biowissenschaften · 2021
    Review
  19. Article
  20. Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sean P CorneliusDepartment of Physics and Astronomy, Northwestern University, Evanston, Illinois 60208, USA.
William L Kath
Adilson E Motter

Funding

TRANS-NETWORK PROJECTSU54CA143869 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WIDOM, JONATHAN · 2009 to 2013
$12.8M
NCI NIH HHS 1U54CA143869-01NCI NIH HHS U54 CA143869
6 · The paper itself

Abstract

The control of complex networks is of paramount importance in areas as diverse as ecosystem management, emergency response and cell reprogramming. A fundamental property of networks is that perturbations to one node can affect other nodes, potentially causing the entire system to change behaviour or fail. Here we show that it is possible to exploit the same principle to control network behaviour. Our approach accounts for the nonlinear dynamics inherent to real systems, and allows bringing the system to a desired target state even when this state is not directly accessible due to constraints that limit the allowed interventions. Applications show that this framework permits reprogramming a network to a desired task, as well as rescuing networks from the brink of failure-which we illustrate through the mitigation of cascading failures in a power-grid network and the identification of potential drug targets in a signalling network of human cancer.

Indexed as

Signal TransductionCell SurvivalHumansLeukemia, Large Granular LymphocyticModels, BiologicalPower PlantsT-Lymphocytes

Identifiers

PMID23803966
PMCPMC3955710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.