Evidence map›Paper›PMID 23803884›Full record

Trial reportThe American journal of clinical nutrition2013

Long-term effects of LCPUFA supplementation on childhood cognitive outcomes.

John Colombo, Susan E Carlson, Carol L Cheatham, D Jill Shaddy, Elizabeth H Kerling, Jocelynn M Thodosoff, Kathleen M Gustafson, Caitlin Brez

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00266825 (Kansas University DHA Outcome Study), which is not on this map. Cited by 83 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00266825 phase3completednot on this map

Kansas University DHA Outcome Study (KUDOS)

TypeinterventionalSponsorSusan Carlson, PhDRan2006 to 2011Enrolled350ConditionsPregnancyArmsDHA, Placebo capsule
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

John ColomboSchiefelbusch Life Span Institute and Department of Psychology, University of Kansas, Kansas City, KS 66160, USA. scarlson@kumc.edu
Susan E Carlson
Carol L Cheatham
D Jill Shaddy
Elizabeth H Kerling
Jocelynn M Thodosoff
Kathleen M Gustafson
Caitlin Brez

Funding

Research Design and Analysis Core (RDAC)P30HD002528 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 1985 to 2015
$22.1M
Participant Recruitment and ManagementP30DC005803 · NIDCD · UNIVERSITY OF KANSAS LAWRENCE · PI RICE, MABEL L · 2002 to 2016
$5.8M
DHA Supplementation and Pregnancy OutcomeR01HD047315 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CARLSON, SUSAN E, COLOMBO, JOHN A. · 2006 to 2016
$4.9M
The Effects of Docosahexaenoic acid (DHA) on fetal cardiac outcomesR21HD059019 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI GUSTAFSON, KATHLEEN M · 2009 to 2010
$411k
NICHD NIH HHS P30 HD02528NICHD NIH HHS R01 HD047315NICHD NIH HHS R21 HD059019NIDCD NIH HHS P30 DC005803
6 · The paper itself

Abstract

backgroundThe effect of long-chain polyunsaturated fatty acid (LCPUFA) intake on cognitive development is controversial. Most randomized trials have assessed cognition at 18 mo, although significant development of cognitive abilities (early executive function) emerge later.

objectiveThe objective was to evaluate cognition beyond 18 mo and longitudinal cognitive change from 18 mo to 6 y in children who were fed variable amounts of docosahexaenoic acid (0.32%, 0.64%, and 0.96% of total fatty acids) and arachidonic acid (ARA; 0.64%) compared with children who were not fed LCPUFA as infants.

designEighty-one children (19 placebo, 62 LCPUFA) who participated in a double-blind, randomized trial of LCPUFA supplementation as infants were re-enrolled at 18 mo and tested every 6 mo until 6 y on age-appropriate standardized and specific cognitive tests.

resultsLCPUFA supplementation did not influence performance on standardized tests of language and performance at 18 mo; however, significant positive effects were observed from 3 to 5 y on rule-learning and inhibition tasks, the Peabody Picture Vocabulary Test at 5 y, and the Weschler Primary Preschool Scales of Intelligence at 6 y. Effects of LCPUFAs were not found on tasks of spatial memory, simple inhibition, or advanced problem solving.

conclusionsThe data from this relatively small trial suggest that, although the effects of LCPUFAs may not always be evident on standardized developmental tasks at 18 mo, significant effects may emerge later on more specific or fine-grained tasks. The results imply that studies of nutrition and cognitive development should be powered to continue through early childhood. This parent trial was registered at clinicaltrials.gov as NCT00266825.

Indexed as

Dietary SupplementsInfant Nutritional Physiological PhenomenaChild, PreschoolCognitionDouble-Blind MethodExecutive FunctionFatty Acids, UnsaturatedFemaleFollow-Up StudiesHumansInfantIntelligenceLongitudinal StudiesMaleMemoryProblem SolvingFatty Acids, Unsaturated

Identifiers

PMID23803884
PMCPMC3712550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.