ArticleMolecules (Basel, Switzerland)2013
Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Development and Preclinical Safety Evaluation of an Injectable β-Caryophyllene Nanoemulsion.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Anti-depressant effect of Naringenin-loaded hybridized nanoparticles in diabetic rats via PPARγ/NLRP3 pathway.Scientific reports · 2024Article
- The Use ofBiomedicines · 2024Review
- Intramuscular compatibility of an injectable anti-inflammatory nanodispersion from a standardized Bixa orellana oil (ChronicInflammopharmacology · 2023Article
- A Review of Clinical and Preclinical Studies on the Therapeutic Potential of Black Seeds (Journal of pharmacopuncture · 2023Review
- Hepatoprotective Effects of Bioflavonoid Luteolin Using Self-Nanoemulsifying Drug Delivery System.Molecules (Basel, Switzerland) · 2021Article
- Solubility Determination, Hansen Solubility Parameters and Thermodynamic Evaluation of Thymoquinone in (Isopropanol + Water) Compositions.Molecules (Basel, Switzerland) · 2021Article
- Anti-Inflammatory Effects of Thymoquinone in Atherosclerosis: A Mini Review.Frontiers in pharmacology · 2021Review
- Thymoquinone (2-Isoprpyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Review
- The Effects of Thymoquinone Against Morphine-induced Damages on Male Mice Liver.International journal of preventive medicine · 2018Article
- Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders.Oxidative medicine and cellular longevity · 2018Review
- Sex and Gender Dimensions in Hazard and Risk Assessment of Engineered Nanomaterials.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. A newly developed thymoquinone-rich fraction nanoemulsion (TQRFNE) has been prepared using a high pressure homogenizer. The purpose of this study was to investigate the potential acute toxicity of this nanoemulsion in Sprague Dawley rats. The acute toxicity studies were conducted as per the OECD guidelines 425, allowing for the use of test dose limit of 20 mL TQRFNE (containing 44.5 mg TQ)/kg. TQRFNE and distilled water (DW) as a control were administered orally to both sexes of rats on Day 0 and observed for 14 days. All the animals appeared normal, and healthy throughout the study. There was no observed mortality or any signs of toxicity during the experimental period. The effects of the TQRFNE and DW groups on general behavior, body weight, food and water consumption, relative organ weight, hematology, histopathology, and clinical biochemistry were measured. All the parameters measured were unaffected as compared to the control (DW) group. The administration of 20 mL TQRFNE /kg was not toxic after an acute exposure.
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