ArticleNature communications2013
Homeostatic regulation of dendritic dynamics in a motor map in vivo.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Astrocyte regulation of critical period plasticity across neural circuits.Current opinion in neurobiology · 2025Review
- Structure and Topography of Facial Branchiomotor Neuron Dendrites in Larval Zebrafish (Danio rerio).The Journal of comparative neurology · 2024Article
- Article
- Optogenetic stimulation shapes dendritic trees of infragranular cortical pyramidal cells.Frontiers in cellular neuroscience · 2023Article
- Dendrite regeneration in the vertebrate spinal cord.Developmental biology · 2022Article
- The Temporal Mechanisms Guiding Interneuron Differentiation in the Spinal Cord.International journal of molecular sciences · 2021Review
- Orderly compartmental mapping of premotor inhibition in the developing zebrafish spinal cord.Science (New York, N.Y.) · 2020Article
- Central and peripheral innervation patterns of defined axial motor units in larval zebrafish.The Journal of comparative neurology · 2019Article
- Principles Governing Locomotion in Vertebrates: Lessons From Zebrafish.Frontiers in neural circuits · 2018Review
- Spatial patterning of excitatory and inhibitory neuropil territories during spinal circuit development.The Journal of comparative neurology · 2017Article
- In Vivo Measurement of Glycine Receptor Turnover and Synaptic Size Reveals Differences between Functional Classes of Motoneurons in Zebrafish.Current biology : CB · 2017Article
- Neuronal activity biases axon selection for myelination in vivo.Nature neuroscience · 2015Article
- Article
- Selective responses to tonic descending commands by temporal summation in a spinal motor pool.Neuron · 2014Article
- A synaptic mechanism for network synchrony.Frontiers in cellular neuroscience · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Neurons and circuits are remarkably dynamic. Their gross structure can change within minutes as neurons sprout and retract processes to form new synapses. Homeostatic processes acting to regulate neuronal activity contribute to these dynamics and predict that the dendritic dynamics within pools of neurons should vary systematically in accord with the activity levels of individual neurons in the pool during behaviour. Here we test this by taking advantage of a topographic map of recruitment of spinal motoneurons in zebrafish. In vivo imaging reveals that the dendritic filopodial dynamics of motoneurons map onto their recruitment pattern, with the most electrically active cells having the lowest dynamics. Genetic reduction of activity inverts this map of dynamics. We conclude that homeostatic mechanisms driven by a gradient of activity levels in a pool of neurons can drive an associated gradation in neuronal dendritic dynamics, potentially shaping connectivity within a functionally heterogenous pool of neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.