ArticleJournal of physiological anthropology2013
Association between alkaline phosphatase and hypertension in a rural Japanese population: the Nagasaki Islands study.
Article in Journal of physiological anthropology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Coffee consumption in relation to circadian syndrome in US population: a cross-sectional study.Nutrition journal · 2026Article
- Vitamin B6 (Pyridoxal 5' Phosphate) antagonises carotid body P2X3 receptors in hypertension.Cardiovascular research · 2026Article
- Sex-Specific Associations of Serum Alkaline Phosphatase With Metabolic Syndrome and Its Components: Over 15 Years of Follow-Up Among Iranian Adults.Journal of clinical laboratory analysis · 2025Article
- Association of alkaline-phosphatase/albumin ratio with all-cause mortality in critically ill patients with ischemic stroke: a retrospective study.Frontiers in neurology · 2025Article
- The relationship between liver enzymes, prehypertension and hypertension in the Azar cohort population.BMC cardiovascular disorders · 2024Article
- Investigating the relationship between liver enzymes and incidence of hypertension: A population-based cohort study in Kharameh, a city in the South of Iran.Health science reports · 2023Article
- Association between serum liver enzymes and hypertension using propensity score matching analysis: evidence from a large kurdish prospective cohort study.BMC cardiovascular disorders · 2022Article
- Article
- Preoperative Serum Alkaline Phosphatase and Neurological Outcome of Cerebrovascular Surgery.Journal of clinical medicine · 2022Article
- Evaluation of Relationship between Serum Liver Enzymes and Hypertension: A Cross-Sectional Study Based on Data from Rafsanjan Cohort Study.International journal of hypertension · 2022Article
- Associations of Inflammation with Risk of Cardiovascular and All-Cause Mortality in Adults with Hypertension: An Inflammatory Prognostic Scoring System.Journal of inflammation research · 2022Article
- Low serum 25-hydroxyvitamin D levels are associated with liver injury markers in the US adult population.Public health nutrition · 2020Article
- Association between serum liver enzymes and hypertension: a cross-sectional study in Bangladeshi adults.BMC cardiovascular disorders · 2020Article
- Alkaline phosphatase: a potential biomarker for stroke and implications for treatment.Metabolic brain disease · 2019Review
- Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels.Journal of physiological anthropology · 2017Article
- Association between circulating CD34-positive cells and serum alkaline phosphatase in relation to body mass index for elderly Japanese men.Journal of physiological anthropology · 2016Article
- Possible association between serum alkaline phosphatase concentration and thoracicacute aortic dissection.International journal of clinical and experimental medicine · 2015Article
- Increased serum alkaline phosphatase and serum phosphate as predictors of mortality after stroke.Journal of clinical and diagnostic research : JCDR · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough serum alkaline phosphatase (ALP) levels have been associated with hypertension, and ALP is known as an enzyme affected by alcohol consumption, no study has been published on the associations between ALP and the risk of hypertension in relation to drinking status.
methodsWe conducted a cross-sectional study of 2,681 participants (837 men and 1,846 women) aged 30 to 89 years undergoing a general health check-up to investigate the associations between ALP and hypertension in relation to drinking status.
resultsOf the 2,681 participants, 1,549 (514 men and 1,035 women) were diagnosed with hypertension. A sex difference was observed for the relationship between ALP and hypertension. While no significant association was observed for men, the association was significantly positive for women. The multivariable adjusted odds ratio and 95% coincidence interval (CI) of hypertension per increment of 1-log ALP were 0.95 (95% CI: 0.56 to 1.59) for men and 1.57 (95% CI: 1.07 to 2.33) for women. When this analysis was restricted to nondrinkers, a significantly elevated risk of hypertension was observed for men and remained significant for women; that is, 3.32 (95% CI: 1.38 to 8.02) for men and 1.68 (95% CI: 1.11 to 2.55) for women.
conclusionALP is associated with hypertension for both male and female nondrinkers, but not for drinkers. For analyses of associations between ALP and blood pressure, alcohol consumption should thus be considered a potential confounder.
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