ArticleBiology of reproduction2013
The unique expression and function of miR-424 in human placental trophoblasts.
Article in Biology of reproduction, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- microRNA signatures associated with fetal growth restriction: a systematic review.European journal of clinical nutrition · 2022Pooled it
- miR‑424‑5p is downregulated in the placentas of patients with preeclampsia and affects trophoblast migration and invasion.Experimental and therapeutic medicine · 2023Article
- Ultrasound and microbubble-mediated delivery of miR-424-5p has a therapeutic effect in preeclampsia.Biological procedures online · 2023Article
- Intracellular and extracellular factors of colorectal cancer liver metastasis: a pivotal perplex to be fully elucidated.Cancer cell international · 2022Review
- RNA Network Interactions During Differentiation of Human Trophoblasts.Frontiers in cell and developmental biology · 2021Article
- HHV-6A Infection of Endometrial Epithelial Cells Affects miRNA Expression and Trophoblast Cell Attachment.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- The role of NUDT21 in microRNA-binging sites of EZH2 gene increases the of risk preeclampsia.Journal of cellular and molecular medicine · 2019Article
- H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism.Cellular and molecular life sciences : CMLS · 2019Review
- Article
- Exposure to maternal obesity alters gene expression in the preimplantation ovine conceptus.BMC genomics · 2018Article
- Gestational Hypoxia and Developmental Plasticity.Physiological reviews · 2018Review
- miR-518b Enhances Human Trophoblast Cell Proliferation Through Targeting Rap1b and Activating Ras-MAPK Signal.Frontiers in endocrinology · 2018Article
- Cancer Stem Cells: Emergent Nature of Tumor Emergency.Frontiers in genetics · 2018Article
- Article
- Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib.Clinical and translational medicine · 2017Article
- Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications.Journal of pregnancy · 2017Review
- Double hit of NEMO gene in preeclampsia.PloS one · 2017Article
- Intact feto-placental growth in microRNA-210 deficient mice.Placenta · 2016Article
- Placental Origins of Chronic Disease.Physiological reviews · 2016Review
- Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placenta.Cell adhesion & migration · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Placental hypoperfusion causes cellular hypoxia and is associated with fetal growth restriction and preeclampsia. In response to hypoxia, the repertoire of genes expressed in placental trophoblasts changes, which influences key cellular processes such as differentiation and fusion. Diverse miRNAs were recently found to modulate the cellular response to hypoxia. Here we show that miR-424, which was previously shown to be upregulated by hypoxia in nontrophoblastic cell types, is uniquely downregulated in primary human trophoblasts by hypoxia or chemicals known to hinder cell differentiation. We also identify FGFR1 as a direct target of miR-424 in human trophoblasts. This effect is unique to miR-424 and is not seen with other members of this miRNA family that are expressed in trophoblasts, such as miR-15 and miR-16. Our findings establish a unique role for miR-424 during differentiation of human trophoblasts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.