SynthesisBMC systems biology2013
Transcriptome meta-analysis reveals a central role for sex steroids in the degeneration of hippocampal neurons in Alzheimer's disease.
Synthesis in BMC systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Alzheimer's disease as a women's health challenge: a call for action on integrative precision medicine approaches.npj women's health · 2024Review
- Application of Human Brain Organoids-Opportunities and Challenges in Modeling Human Brain Development and Neurodevelopmental Diseases.International journal of molecular sciences · 2023Review
- Reduced Hippocampal and Anterior Cingulate Expression of Antioxidant Enzymes and Membrane Progesterone Receptors in Alzheimer's Disease with Depression.Journal of Alzheimer's disease : JAD · 2022Article
- Sex Differences in Alzheimer's Disease: Insights From the Multiomics Landscape.Biological psychiatry · 2022Review
- Epigenetics of the developing and aging brain: Mechanisms that regulate onset and outcomes of brain reorganization.Neuroscience and biobehavioral reviews · 2021Review
- Selective Targeting of Non-nuclear Estrogen Receptors with PaPE-1 as a New Treatment Strategy for Alzheimer's Disease.Neurotoxicity research · 2020Article
- Sex-dependent effect ofDisease models & mechanisms · 2020Review
- Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.Frontiers in immunology · 2020Article
- An Improved CRISPR/dCas9 Interference Tool for Neuronal Gene Suppression.Frontiers in genome editing · 2020Article
- Molecular windows into the human brain for psychiatric disorders.Molecular psychiatry · 2019Review
- The expression of select genes necessary for membrane-associated estrogen receptor signaling differ by sex in adult rat hippocampus.Steroids · 2019Article
- Data-Driven Analysis of Age, Sex, and Tissue Effects on Gene Expression Variability in Alzheimer's Disease.Frontiers in neuroscience · 2019Article
- Steroid and Xenobiotic Receptor Signalling in Apoptosis and Autophagy of the Nervous System.International journal of molecular sciences · 2017Review
- Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology.Molecular neurobiology · 2017Article
- Global gene expression profiling of healthy human brain and its application in studying neurological disorders.Scientific reports · 2017Article
- Article
- Review on Graph Clustering and Subgraph Similarity Based Analysis of Neurological Disorders.International journal of molecular sciences · 2016Review
- Neural Androgen Receptor Deletion Impairs the Temporal Processing of Objects and Hippocampal CA1-Dependent Mechanisms.PloS one · 2016Article
- Systems biology surveillance decrypts pathological transcriptome remodeling.BMC systems biology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlzheimer's disease is the most prevalent form of dementia. While a number of transcriptomic studies have been performed on the brains of Alzheimer's specimens, no clear picture has emerged on the basis of neuronal transcriptional alterations linked to the disease. Therefore we performed a meta-analysis of studies comparing hippocampal neurons in Alzheimer's disease to controls.
resultsHomeostatic processes, encompassing control of gene expression, apoptosis, and protein synthesis, were identified as disrupted during Alzheimer's disease. Focusing on the genes carrying out these functions, a protein-protein interaction network was produced for graph theory and cluster exploration. This approach identified the androgen and estrogen receptors as key components and regulators of the disrupted homeostatic processes.
conclusionsOur systems biology approach was able to identify the importance of the androgen and estrogen receptors in not only homeostatic cellular processes but also the role of other highly central genes in Alzheimer's neuronal dysfunction. This is important due to the controversies and current work concerning hormone replacement therapy in postmenopausal women, and possibly men, as preventative approaches to ward off this neurodegenerative disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.