Evidence map›Paper›PMID 23803260›Full record

ArticlePsychological medicine2014

Pre- and perinatal hypoxia associated with hippocampus/amygdala volume in bipolar disorder.

U K Haukvik, T McNeil, E H Lange, I Melle, A M Dale, O A Andreassen, I Agartz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Parental asthma and risk of autism spectrum disorder in offspring: A population and family-based case-control study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019
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  15. Stereological investigation of the posterior hippocampus in affective disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2015
    Article
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  19. Genetics of bipolar disorder.The application of clinical genetics · 2014
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

U K HaukvikDepartment of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
T McNeilDepartment of Psychiatric Epidemiology, Lund University, Lund, Sweden.
E H LangeDepartment of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
I MelleK. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
A M DaleDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
O A AndreassenK. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
I AgartzDepartment of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Oslo University Hospital · NOUniversity of Oslo · NODiakonhjemmet Hospital · NOLund University · SEUniversity of California, San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPre- and perinatal adversities may increase the risk for schizophrenia and bipolar disorder. Hypoxia-related obstetric complications (OCs) are associated with brain anatomical abnormalities in schizophrenia, but their association with brain anatomy variation in bipolar disorder is unknown.

methodMagnetic resonance imaging brain scans, clinical examinations and data from the Medical Birth Registry of Norway were obtained for 219 adults, including 79 patients with a DSM-IV diagnosis of bipolar disorder (age 29.4 years, s.d. = 11.8 years, 39% male) and 140 healthy controls (age 30.8 years, s.d. = 12.0 years, 53% male). Severe hypoxia-related OCs throughout pregnancy/birth and perinatal asphyxia were each studied in relation to a priori selected brain volumes (hippocampus, lateral ventricles and amygdala, obtained with FreeSurfer), using linear regression models covarying for age, sex, medication use and intracranial volume. Multiple comparison adjustment was applied.

resultsPerinatal asphyxia was associated with smaller left amygdala volume (t = -2.59, p = 0.012) in bipolar disorder patients, but not in healthy controls. Patients with psychotic bipolar disorder showed distinct associations between perinatal asphyxia and smaller left amygdala volume (t = -2.69, p = 0.010), whereas patients with non-psychotic bipolar disorder showed smaller right hippocampal volumes related to both perinatal asphyxia (t = -2.60, p = 0.015) and severe OCs (t = -3.25, p = 0.003). No associations between asphyxia or severe OCs and the lateral ventricles were found.

conclusionsPre- and perinatal hypoxia-related OCs are related to brain morphometry in bipolar disorder in adulthood, with specific patterns in patients with psychotic versus non-psychotic illness.

Indexed as

AdolescentAdultAmygdalaAsphyxia NeonatorumBipolar DisorderComorbidityFemaleFetal HypoxiaHippocampusHumansMagnetic Resonance ImagingMaleNorwayRegistriesYoung Adult

Identifiers

PMID23803260
PMCPMC3936825
OpenAlexW2099292447

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.