ArticleCell communication and signaling : CCS2013
Mathematical modeling of apoptosis.
Article in Cell communication and signaling : CCS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Review
- Autism risk geneFrontiers in cellular neuroscience · 2024Article
- Bistability regulates TNFR2-mediated survival and death of T-regulatory cells.Journal of biological physics · 2023Article
- NF-kB in Signaling Patterns and Its Temporal Dynamics Encode/Decode Human Diseases.Life (Basel, Switzerland) · 2022Review
- Mathematical Models of Death Signaling Networks.Entropy (Basel, Switzerland) · 2022Review
- An integrative systems biology approach to overcome venetoclax resistance in acute myeloid leukemia.PLoS computational biology · 2022Article
- A probabilistic Boolean model on hair follicle cell fate regulation by TGF-β.Biophysical journal · 2022Article
- TSMiner: a novel framework for generating time-specific gene regulatory networks from time-series expression profiles.Nucleic acids research · 2021Article
- Fate decisions mediated by crosstalk of autophagy and apoptosis in mammalian cells.Journal of biological physics · 2020Article
- Systems biology of ferroptosis: A modeling approach.Journal of theoretical biology · 2020Article
- A Probabilistic Approach to Explore Signal Execution Mechanisms With Limited Experimental Data.Frontiers in genetics · 2020Article
- Rhein Induces Cell Death in HepaRG Cells through Cell Cycle Arrest and Apoptotic Pathway.International journal of molecular sciences · 2018Article
- A Novel Data-Driven Boolean Model for Genetic Regulatory Networks.Frontiers in physiology · 2018Article
- Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics.Frontiers in physiology · 2017Article
- Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?Cell death & disease · 2016Review
- A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient.Frontiers in pharmacology · 2016Review
- HSP70 mediates survival in apoptotic cells-Boolean network prediction and experimental validation.Frontiers in cellular neuroscience · 2015Article
- Systems biology of death receptor networks: live and let die.Cell death & disease · 2014Review
- A conceptual review on systems biology in health and diseases: from biological networks to modern therapeutics.Systems and synthetic biology · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apoptosis is a form of programmed cell death, which is fundamental to all multicellular organisms. Deregulation of apoptosis leads to a number of severe diseases including cancer. Apoptosis is initiated either by extrinsic signals via stimulation of receptors at the cellular surface or intrinsic signals, such as DNA damage or growth factor withdrawal. Apoptosis has been extensively studied using systems biology which substantially contributed to the understanding of this death signaling network. This review gives an overview of mathematical models of apoptosis and the potential of systems biology to contribute to the development of novel therapies for cancer or other apoptosis-related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.