ArticleAnnals of the American Thoracic Society2013
Adult-onset asthma becomes the dominant phenotype among women by age 40 years. the longitudinal CARDIA study.
Article in Annals of the American Thoracic Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and risk factors for childhood asthma: a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Obesity and weight change during eight years in relation to asthma incidence.Scientific reports · 2025Article
- Asthma Phenotypes and Biomarkers.Respiratory care · 2025Review
- Tumor Necrotic Factor-Alpha (-308A/G, rs1800629) and Interleukin-13 (R130Q, rs20541) Gene Polymorphisms as Predictors of Severe Asthma in Pilot Cohort of Kuwaiti Population: Influence of Age, Nasal Polyps, Fractional Exhaled Nitric Oxide, and Blood Eosinophil Count.Journal of asthma and allergy · 2025Article
- Characteristics of Older Individuals with Asthma Being Treated with Biologics.Journal of asthma and allergy · 2025Article
- Lifetime asthma incidence is related to age at onset and allergies in western Sweden.Clinical and translational allergy · 2024Article
- Adult-onset asthma induced by COVID-19: A case report.Heliyon · 2024Article
- Effect of air pollution on asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Review
- Agreement between self-reported and registered age at asthma diagnosis in Finland.BMC pulmonary medicine · 2024Article
- Factors associated with self-reported diagnosed asthma in urban and rural Malawi: Observations from a population-based study of non-communicable diseases.PLOS global public health · 2024Article
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- Revealing polygenic pleiotropy using genetic risk scores for asthma.HGG advances · 2023Article
- Peripheral blood eosinophilia in adult asthmatic patients and its association with the severity of asthma.BMC pulmonary medicine · 2023Article
- Subtypes of Adult-Onset Asthma at the Time of Diagnosis: A Latent Class Analysis.International journal of environmental research and public health · 2023Article
- Age at asthma diagnosis and onset of symptoms among adults with allergic and non-allergic asthma.European clinical respiratory journal · 2023Article
- Different Characteristics and Clinical Outcomes between Early-Onset and Late-Onset Asthma: A Prospective Cohort Study.Journal of clinical medicine · 2022Article
- Recent miRNA Research in Asthma.Current allergy and asthma reports · 2022Review
- Depression in Childhood Asthma vs. Adult-Onset Asthma: A Cross-Sectional Study from the National Health and Nutrition Examination Survey (NHANES).Children (Basel, Switzerland) · 2022Article
- Participation in scheduled asthma follow-up contacts and adherence to treatment during 12-year follow-up in patients with adult-onset asthma.BMC pulmonary medicine · 2022Observational
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Authors and funding
7 authors.
Funding
Abstract
rationaleAlthough asthma is usually considered to originate in childhood, adult-onset disease is being increasingly reported.
objectivesTo contrast the proportion and natural history of adult-onset versus pediatric-onset asthma in a community-based cohort. We hypothesized that asthma in women is predominantly of adult onset rather than of pediatric onset.
methodsThis study used data from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort in the United States over a 25-year period. Adult- and pediatric-onset asthma phenotypes were studied, as defined by age at onset of 18 years or older. Subjects with asthma were categorized by sex, obesity, atopy, smoking, and race by mean age/examination year, using a three-way analysis of covariance model. Natural history of disease was examined using probabilities derived from a Markov chain model. MEASUREMENTS AND MAIN
resultsAsthma of adult onset became the dominant (i.e., exceeded 50%) phenotype in women by age 40 years. The age by which adult-onset asthma became the dominant phenotype was further lowered for obese, nonatopic, ever-smoking, or white women. The prevalence trend with increasing time for adult-onset disease was greater among subjects with nonatopic than atopic asthma among both sexes. Furthermore, adult-onset asthma had remarkable sex-related differences in risk factors. In both sexes, the quiescent state for adult-onset asthma was less frequent and also "less stable" over time than for pediatric-onset asthma.
conclusionsUsing a large national cohort, this study challenges the dictum that most asthma in adults originates in childhood. Studies of the differences between pediatric- and adult-onset asthma may provide greater insight into the phenotypic heterogeneity of asthma.
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