Evidence map›Paper›PMID 23802653›Full record

ReviewJournal of cellular and molecular medicine2013

Advances in the treatment of acute graft-versus-host disease.

Liren Qian, Zhengcheng Wu, Jianliang Shen

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07708987 phase2recruitingnot on this mapstarted 2023, after this paper: background citation

A Phase II Clinical Trial of Standardized Withaferin-A for the Treatment of Steroid Refractory Acute Graft Versus Host Disease

TypeinterventionalSponsorTata Memorial CentreRan2023 to 2028Enrolled34ConditionsHematological Malignancy, GVHD - Graft-Versus-Host Disease, Steriod RefractoryArmsStandardized Withaferin A (SWA)
NCT07724873 phase1 / phase2recruitingnot on this mapstarted 2025, after this paper: background citation

A Phase I/II Trial to Assess Safety and Activity of Standardized Withaferin A as GvHD Prophylaxis in Patients Undergoing Matched Related Donor Hematopoietic Stem Cell Transplant

TypeinterventionalSponsorTata Memorial CentreRan2025 to 2029Enrolled54ConditionsHematopoietic Stem Cell Transplant (HSCT), GVHD - Graft-Versus-Host Disease, Hematological MalignancyArmsSWA (standardized root extract of Withania somnifera)
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Medical Application of Hydrogen in Hematological Diseases.Oxidative medicine and cellular longevity · 2019
    Review
  9. Article
  10. Review
  11. Review
  12. CD28 BlockadeFrontiers in immunology · 2017
    Article
  13. Review
  14. Article
  15. Article
  16. Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Article
  17. Article
  18. Review
  19. Administration of hydrogen-rich saline in mice with allogeneic hematopoietic stem-cell transplantation.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Liren QianDepartment of Haematology, Navy General Hospital, Beijing, China. qlr2007@126.com
Zhengcheng Wu
Jianliang Shen
PLA Navy General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) has been widely used for the treatment of hematologic malignant and non-malignant hematologic diseases and other diseases. However, acute graft-versus-host disease (GVHD) is a life-threatening complication of allogeneic transplantation. Acute GVHD may occur in 30% of transplant recipients, which is a syndrome of erythematous skin eruption, cholestatic liver disease and intestinal dysfunction, resulting from the activation of donor T lymphocytes by host antigen-presenting cells, resulting in an immune-mediated inflammatory response. Recent scientific advances in the understanding of the pathogenesis involved in the development of acute GVHD and clinical investigation have provided more effective therapeutic strategies for acute GVHD. This review focuses on major scientific and clinical advances in the treatment of acute GVHD.

Indexed as

Acute DiseaseGraft vs Host DiseaseHumansImmunosuppression TherapyAcute graft-versus-host diseasehydrogenstem cell transplantationtreatment

Identifiers

PMID23802653
PMCPMC3780546
OpenAlexW1970674255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.