ArticleBioMed research international2013
Mineral and matrix changes in Brtl/+ teeth provide insights into mineralization mechanisms.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Collagen mutation and age contribute to differential craniofacial phenotypes in mouse models of osteogenesis imperfecta.JBMR plus · 2024Article
- Between a rock and a hard place: Regulation of mineralization in the periodontium.Genesis (New York, N.Y. : 2000) · 2022Review
- Deficiency of Mineralization-Regulating Transcription Factor Trps1 Compromises Quality of Dental Tissues and Increases Susceptibility to Dental Caries.Frontiers in dental medicine · 2022Article
- Review
- Dental and craniofacial defects in the CrtapDevelopmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Dentoalveolar Defects in theJournal of dental research · 2020Article
- Trps1 transcription factor regulates mineralization of dental tissues and proliferation of tooth organ cells.Molecular genetics and metabolism · 2019Article
- Bone mineral properties in growing Col1a2(+/G610C) mice, an animal model of osteogenesis imperfecta.Bone · 2016Article
- Article
- Animal models of osteogenesis imperfecta: applications in clinical research.Orthopedic research and reviews · 2016Review
- Studying variations in bone composition at nano-scale resolution: a preliminary report.Calcified tissue international · 2014Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The Brtl/+ mouse is a knock-in model for osteogenesis imperfecta type IV in which a Gly349Cys substitution was introduced into one COL1A1 allele. To gain insight into the changes in dentin structure and mineral composition in these transgenic mice, the objective of this study was to use microcomputed tomography (micro-CT), scanning electron microscopy (SEM), and Fourier transform infrared imaging (FTIRI) to analyze these structures at 2 and 6 months of age. Results, consistent with the dental phenotype in humans with type IV OI, showed decreased molar volume and reduced mineralized tissue volume in the teeth without changes in enamel properties. Increased acid phosphate content was noted at 2 and 6 months by FTIRI, and a trend towards altered collagen structure was noted at 2 but not 6 months in the Brtl/+ teeth. The increase in acid phosphate content suggests a delay in the mineralization process, most likely associated with the defect in the collagen structure. It appears that in the Brtl/+ teeth slow maturation of the mineralized structures allows correction of altered mineral content and acid phosphate distribution.
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Registered trials
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