Evidence map›Paper›PMID 23802088›Full record

ArticleOncoimmunology2013

Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy.

Stephanie Chang, Xue Lin, Ryuji Higashikubo, Kelsey Toth, Andrew E Gelman, Daniel Kreisel, Alexander S Krupnick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Immunotherapy for lung cancer: for whom the bell tolls?Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephanie ChangDepartment of Surgery, Division of Cardiothoracic Surgery, Alvin Siteman Cancer Center and Department of Pathology and Immunology Washington University School of Medicine.
Xue Lin
Ryuji Higashikubo
Kelsey Toth
Andrew E Gelman
Daniel Kreisel
Alexander S Krupnick

Funding

THE ROLE OF ISCHEMIA REPERFUSION INJURY IN LUNG ALLOGRAFT REJECTIONR01HL094601 · NHLBI · WASHINGTON UNIVERSITY · PI Andrew Eric Gelman, Daniel Kreisel · 2009 to 2026
$6.9M
MECHANISMS OF LUNG ALLOGRAFT ACCEPTANCER01HL113931 · NHLBI · WASHINGTON UNIVERSITY · PI KREISEL, DANIEL, KRUPNICK, ALEXANDER S. · 2012 to 2015
$1.5M
The Role of Non-Hematopoietic Cells in Tumor Tolerance InductionK08CA131097 · NCI · WASHINGTON UNIVERSITY · PI KRUPNICK, ALEXANDER S. · 2008 to 2012
$710k
Immunoregulation of the Pulmonary Environment by Non-Hematopoietic Stromal CellsF32HL114270 · NHLBI · WASHINGTON UNIVERSITY · PI CHANG, STEPHANIE HILARY · 2012 to 2013
$100k
NCI NIH HHS K08 CA131097NHLBI NIH HHS F32 HL114270NHLBI NIH HHS R01 HL094601NHLBI NIH HHS R01 HL113931
6 · The paper itself

Abstract

Unlike other tumors, lung cancer appears to be poorly sensitive to immunotherapy. We have recently demonstrated an alternative pathway of lung cancer immunosurveillance. Our data indicate a failure of the adaptive immune system to mediate the immunosurveillance of lung cancer and emphasize the prominent role of natural killer cells in this setting.

Indexed as

adoptive immune systemimmunotherapylung cancermucosal antigen presentationnatural killer cells

Identifiers

PMID23802088
PMCPMC3661173

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.