ArticleCommunicative & integrative biology2013
Cracking the bioelectric code: Probing endogenous ionic controls of pattern formation.
Article in Communicative & integrative biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
83 citing papers in PubMed, 180 citations in OpenAlex.
- The Multiscale Wisdom of the Body: Collective Intelligence as a Tractable Interface for Next-Generation Biomedicine.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Bioelectricity is a universal multifaced signaling cue in living organisms.Molecular biology of the cell · 2025Review
- Self-Improvising Memory: A Perspective on Memories as Agential, Dynamically Reinterpreting Cognitive Glue.Entropy (Basel, Switzerland) · 2024Article
- Direct coupled electrical stimulation towards improved osteogenic differentiation of human mesenchymal stem/stromal cells: a comparative study of different protocols.Scientific reports · 2024Article
- Future medicine: from molecular pathways to the collective intelligence of the body.Trends in molecular medicine · 2023Review
- Bioelectrical State of Bacteria Is Linked to Growth Dynamics and Response to Neurotransmitters: Perspectives for the Investigation of the Microbiota-Brain Axis.International journal of molecular sciences · 2023Article
- Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine.Patterns (New York, N.Y.) · 2023Review
- Darwin's agential materials: evolutionary implications of multiscale competency in developmental biology.Cellular and molecular life sciences : CMLS · 2023Review
- Review
- Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook.Cold Spring Harbor perspectives in biology · 2022Review
- Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code.International journal of molecular sciences · 2022Review
- Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adultScience advances · 2022Article
- Vitalism and cognition in a conscious universe.Communicative & integrative biology · 2022Article
- Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds.Frontiers in systems neuroscience · 2022Article
- Unveiling the morphogenetic code: A new path at the intersection of physical energies and chemical signaling.World journal of stem cells · 2021Review
- Bioelectric signaling as a unique regulator of development and regeneration.Development (Cambridge, England) · 2021Review
- Biomolecular Basis of Cellular Consciousness via Subcellular Nanobrains.International journal of molecular sciences · 2021Review
- Why isn't sex optional? Stem-cell competition, loss of regenerative capacity, and cancer in metazoan evolution.Communicative & integrative biology · 2020Review
- Dual Bioelectrical Assessment of Human Mesenchymal Stem Cells Using Plasma and Mitochondrial Membrane Potentiometric Probes.Bioelectricity · 2020Article
- Epithelial tissue geometry directs emergence of bioelectric field and pattern of proliferation.Molecular biology of the cell · 2020Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Patterns of resting potential in non-excitable cells of living tissue are now known to be instructive signals for pattern formation during embryogenesis, regeneration and cancer suppression. The development of molecular-level techniques for tracking ion flows and functionally manipulating the activity of ion channels and pumps has begun to reveal the mechanisms by which voltage gradients regulate cell behaviors and the assembly of complex large-scale structures. A recent paper demonstrated that a specific voltage range is necessary for demarcation of eye fields in the frog embryo. Remarkably, artificially setting other somatic cells to the eye-specific voltage range resulted in formation of eyes in aberrant locations, including tissues that are not in the normal anterior ectoderm lineage: eyes could be formed in the gut, on the tail, or in the lateral plate mesoderm. These data challenge the existing models of eye fate restriction and tissue competence maps, and suggest the presence of a bioelectric code-a mapping of physiological properties to anatomical outcomes. This Addendum summarizes the current state of knowledge in developmental bioelectricity, proposes three possible interpretations of the bioelectric code that functionally maps physiological states to anatomical outcomes, and highlights the biggest open questions in this field. We also suggest a speculative hypothesis at the intersection of cognitive science and developmental biology: that bioelectrical signaling among non-excitable cells coupled by gap junctions simulates neural network-like dynamics, and underlies the information processing functions required by complex pattern formation in vivo. Understanding and learning to control the information stored in physiological networks will have transformative implications for developmental biology, regenerative medicine and synthetic bioengineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.