ArticleInternational journal of medical sciences2013
Lack of association of C-Met-N375S sequence variant with lung cancer susceptibility and prognosis.
Article in International journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- The role and research progress of the MET signalling pathway in targeted therapy for osteosarcoma.Oncology reviews · 2025Review
- Therapeutic advances of targeting receptor tyrosine kinases in cancer.Signal transduction and targeted therapy · 2024Review
- Article
- A narrative review of MET inhibitors in non-small cell lung cancer withTranslational lung cancer research · 2021Review
- A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma.Nature communications · 2020Article
- The Role of c-Met as a Biomarker and Player in Innate and Acquired Resistance in Non-Small-Cell Lung Cancer: Two New Mutations Warrant Further Studies.Molecules (Basel, Switzerland) · 2019Article
- Proteolytic cleavages of MET: the divide-and-conquer strategy of a receptor tyrosine kinase.BMB reports · 2019Review
- The multiple paths towards MET receptor addiction in cancer.Oncogene · 2018Review
- MET receptor variant R970C favors calpain-dependent generation of a fragment promoting epithelial cell scattering.Oncotarget · 2017Article
- Establishment and application of a multiplex genetic mutation-detection method of lung cancer based on MassARRAY platform.Cancer biology & medicine · 2016Article
- [Mechanism of c-MET in Non-small Cell Lung Cancer and Its Treatment and Testing].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2015Review
- Article
- MET aberrations and c-MET inhibitors in patients with gastric and esophageal cancers in a phase I unit.Oncotarget · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreviously, we identified a sequence variant (N375S) of c-Met gene, however, its association with lung cancer risk and prognosis remain undefined. PATIENTS AND
methodsWe investigated the genotype distribution of the c-Met-N375S sequence variant in 206 lung cancer patients and 207 non-cancer controls in the Taiwanese population by DNA sequencing.
resultsLung cancer patients with variant A/G and G/G genotypes showed 1.08-fold increased cancer risk when compared to patients with the wild-type A/A genotype (95% CI, 0.60-1.91). There were no significant differences in postoperative survival between c-Met-N375S and wild-type patients. In the cell model, the c-Met-N375S cells showed a decrease in cell death upon treatment with MET inhibitor SU11274 compared to wild-type cells.
conclusionOur data suggest that the c-Met-N375S sequence variant may not play a significant role in cancer susceptibility and the prognosis of lung cancer patients. The correlation with chemoresponse of c-Met-N375S is worth further investigation in patients receiving MET therapy.
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