ArticleProceedings of the National Academy of Sciences of the United States of America2013
Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Application of photodynamic activation of prodrugs combined with phototherapy in tumor treatment.Molecular cancer · 2025Review
- Functionalized Polymeric Micelles for Targeted Cancer Therapy: Steps from Conceptualization to Clinical Trials.Pharmaceutics · 2024Review
- Key processes in tumor metastasis and therapeutic strategies with nanocarriers: a review.Molecular biology reports · 2024Review
- Development of Facile and Versatile Platinum Drug Delivering Silicasome Nanocarriers for Efficient Pancreatic Cancer Chemo-Immunotherapy.Small (Weinheim an der Bergstrasse, Germany) · 2021Article
- In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers.Nature communications · 2019Article
- Improving accessibility of EPR-insensitive tumor phenotypes using EPR-adaptive strategies: Designing a new perspective in nanomedicine delivery.Theranostics · 2019Review
- Differences in Nanoparticle Uptake in Transplanted and Autochthonous Models of Pancreatic Cancer.Nano letters · 2018Article
- Platinum-Based Nanovectors Engineered with Immuno-Modulating Adjuvant for Inhibiting Tumor growth and Promoting Immunity.Theranostics · 2018Article
- Nanotechnology: from In Vivo Imaging System to Controlled Drug Delivery.Nanoscale research letters · 2017Review
- Biological nanoparticles carrying the Hmda-7 gene are effective in inhibiting pancreatic cancer in vitro and in vivo.PloS one · 2017Article
- Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors.International journal of nanomedicine · 2017Review
- Development of polymeric micelles for targeting intractable cancers.Cancer science · 2016Review
- Inhibition of bone loss with surface-modulated, drug-loaded nanoparticles in an intraosseous model of prostate cancer.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
- Functionalized milk-protein-coated magnetic nanoparticles for MRI-monitored targeted therapy of pancreatic cancer.International journal of nanomedicine · 2016Article
- Molecular Targeted Intervention for Pancreatic Cancer.Cancers · 2015Review
- A new approach to reduce toxicities and to improve bioavailabilities of platinum-containing anti-cancer nanodrugs.Scientific reports · 2015Article
- MRI-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model.International journal of nanomedicine · 2015Article
- Self-assembled micellar nanocomplexes comprising green tea catechin derivatives and protein drugs for cancer therapy.Nature nanotechnology · 2014Article
- Potential applications of nanotechnology for the diagnosis and treatment of pancreatic cancer.Frontiers in physiology · 2014Review
- Nanocarriers for delivery of platinum anticancer drugs.Advanced drug delivery reviews · 2013Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoscaled drug-loaded carriers are of particular interest for efficient tumor therapy as numerous studies have shown improved targeting and efficacy. Nevertheless, most of these studies have been performed against allograft and xenograft tumor models, which have altered microenvironment features affecting the accumulation and penetration of nanocarriers. Conversely, the evaluation of nanocarriers on genetically engineered mice, which can gradually develop clinically relevant tumors, permits the validation of their design under normal processes of immunity, angiogenesis, and inflammation. Therefore, considering the poor prognosis of pancreatic cancer, we used the elastase 1-promoted luciferase and Simian virus 40 T and t antigens transgenic mice, which develop spontaneous bioluminescent pancreatic carcinoma, and showed that long circulating micellar nanocarriers, incorporating the parent complex of oxaliplatin, inhibited the tumor growth as a result of their efficient accumulation and penetration in the tumors. The reduction of the photon flux from the endogenous tumor by the micelles correlated with the decrease of serum carbohydrate-associated antigen 19-9 marker. Micelles also reduced the incidence of metastasis and ascites, extending the survival of the transgenic mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.