ArticleDiabetes2013
Impairments in site-specific AS160 phosphorylation and effects of exercise training.
Article in Diabetes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Article
- Effects of aerobic, resistance, interval, and combined training on glucose metabolism in older adults: insights into type, dose, and mechanism.Frontiers in physiology · 2025Review
- Lactate-induced lactylation in skeletal muscle is associated with insulin resistance in humans.Frontiers in physiology · 2022Article
- Nutrition for Older Athletes: Focus on Sex-Differences.Nutrients · 2021Review
- Exercise and insulin resistance in PCOS: muscle insulin signalling and fibrosis.Endocrine connections · 2020Article
- Exercise effects on γ3-AMPK activity, phosphorylation of Akt2 and AS160, and insulin-stimulated glucose uptake in insulin-resistant rat skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Impact of Endurance and Resistance Training on Skeletal Muscle Glucose Metabolism in Older Adults.Nutrients · 2019Review
- Aerobic and resistance exercise training reverses age-dependent decline in NADPhysiological reports · 2019Article
- Whole body glucoregulation and tissue-specific glucose uptake in a novel Akt substrate of 160 kDa knockout rat model.PloS one · 2019Article
- Resistance Exercise Training as a Primary Countermeasure to Age-Related Chronic Disease.Frontiers in physiology · 2019Review
- Effects of Exercise and Aging on Skeletal Muscle.Cold Spring Harbor perspectives in medicine · 2018Review
- Paternal high-fat diet enhances offspring whole-body insulin sensitivity and skeletal muscle insulin signaling early in life.Physiological reports · 2018Article
- The Vicious Cycle of Myostatin Signaling in Sarcopenic Obesity: Myostatin Role in Skeletal Muscle Growth, Insulin Signaling and Implications for Clinical Trials.The Journal of frailty & aging · 2018Review
- Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass.Skeletal muscle · 2017Article
- Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction.Biochemical and biophysical research communications · 2016Article
- Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training.American journal of physiology. Endocrinology and metabolism · 2016Article
- Exercise Promotes Healthy Aging of Skeletal Muscle.Cell metabolism · 2016Review
- Resistance training improves skeletal muscle insulin sensitivity in elderly offspring of overweight and obese mothers.Diabetologia · 2016Article
- Influence of Acute and Chronic Exercise on Glucose Uptake.Journal of diabetes research · 2016Review
- Metformin Treatment Prevents Sedentariness Related Damages in Mice.Journal of diabetes research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The purpose of this study was to determine if site-specific phosphorylation at the level of Akt substrate of 160 kDa (AS160) is altered in skeletal muscle from sedentary humans across a wide range of the adult life span (18-84 years of age) and if endurance- and/or strength-oriented exercise training could rescue decrements in insulin action and skeletal muscle AS160 phosphorylation. A euglycemic-hyperinsulinemic clamp and skeletal muscle biopsies were performed in 73 individuals encompassing a wide age range (18-84 years of age), and insulin-stimulated AS160 phosphorylation was determined. Decrements in whole-body insulin action were associated with impairments in insulin-induced phosphorylation of skeletal muscle AS160 on sites Ser-588, Thr-642, Ser-666, and phospho-Akt substrate, but not Ser-318 or Ser-751. Twelve weeks of endurance- or strength-oriented exercise training increased whole-body insulin action and reversed impairments in AS160 phosphorylation evident in insulin-resistant aged individuals. These findings suggest that a dampening of insulin-induced phosphorylation of AS160 on specific sites in skeletal muscle contributes to the insulin resistance evident in a sedentary aging population and that exercise training is an effective intervention for treating these impairments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.