ArticleMagnetic resonance in medicine2013
Magnetic susceptibility as a B0 field strength independent MRI biomarker of liver iron overload.
Article in Magnetic resonance in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01516853 (Non-invasive Quantification of Liver Iron With MRI), which is not on this map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-invasive Quantification of Liver Iron With MRI
Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
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- Data adaptive regularization with reference tissue constraints for liver quantitative susceptibility mapping.Magnetic resonance in medicine · 2023Article
- Toward a realistic in silico abdominal phantom for QSM.Magnetic resonance in medicine · 2023Article
- Validation of liver quantitative susceptibility mapping across imaging parameters at 1.5 T and 3.0 T using SQUID susceptometry as reference.Magnetic resonance in medicine · 2023Article
- Effects of BJournal of magnetic resonance imaging : JMRI · 2022Article
- Quantitative Susceptibility Mapping Using a Multispectral Autoregressive Moving Average Model to Assess Hepatic Iron Overload.Journal of magnetic resonance imaging : JMRI · 2021Article
- Complex confounder-corrected R2* mapping for liver iron quantification with MRI.European radiology · 2021Article
- A hybrid (iron-fat-water) phantom for liver iron overload quantification in the presence of contaminating fat using magnetic resonance imaging.Magma (New York, N.Y.) · 2020Article
- Evaluation of a motion-robust 2D chemical shift-encoded technique for R2* and field map quantification in ferumoxytol-enhanced MRI of the placenta in pregnant rhesus macaques.Journal of magnetic resonance imaging : JMRI · 2020Article
- Quantitative ferumoxytol-enhanced MRI in pregnancy: A feasibility study in the nonhuman primate.Magnetic resonance imaging · 2020Article
- Quantitative magnetic resonance imaging evaluation of hepatic fat content with iron deposition: will it be disturbed?The Journal of international medical research · 2019Article
- The influence of liver fat deposition on the quantification of the liver-iron fraction using fast-kilovolt-peak switching dual-energy CT imaging and material decomposition technique: anQuantitative imaging in medicine and surgery · 2019Article
- Noninvasive quantification of oxygen saturation in the portal and hepatic veins in healthy mice and those with colorectal liver metastases using QSM MRI.Magnetic resonance in medicine · 2019Article
- Assessment of MR-based R2* and quantitative susceptibility mapping for the quantification of liver iron concentration in a mouse model at 7T.Magnetic resonance in medicine · 2018Article
- Fat spectral modeling on triglyceride composition quantification using chemical shift encoded magnetic resonance imaging.Magnetic resonance imaging · 2018Article
- Quantification of liver iron concentration using the apparent susceptibility of hepatic vessels.Quantitative imaging in medicine and surgery · 2018Article
- Standardized Approach for ROI-Based Measurements of Proton Density Fat Fraction and R2* in the Liver.AJR. American journal of roentgenology · 2017Article
- Mask-Adapted Background Field Removal for Artifact Reduction in Quantitative Susceptibility Mapping of the Prostate.Tomography (Ann Arbor, Mich.) · 2017Article
- Susceptibility-weighted imaging: current status and future directions.NMR in biomedicine · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeMR-based quantification of liver magnetic susceptibility may enable field strength-independent measurement of liver iron concentration (LIC). However, susceptibility quantification is challenging, due to nonlocal effects of susceptibility on the B0 field. The purpose of this work is to demonstrate feasibility of susceptibility-based LIC quantification using a fat-referenced approach.
methodsPhantoms consisting of vials with increasing iron concentrations immersed between oil/water layers, and 27 subjects (9 controls/18 subjects with liver iron overload) were scanned. Ferriscan (1.5 T) provided R2-based reference LIC. Multiecho three-dimensional-SPGR (1.5 T/3 T) enabled fat-water, B0- and R2*-mapping. Phantom iron concentration (mg Fe L(-1)) was estimated from B0 differences (ΔB0) between vials and neighboring oil. Liver susceptibility and LIC (mg Fe g(-1) dry tissue) was estimated from ΔB0 between the lateral right lobe of the liver and adjacent subcutaneous adipose tissue.
resultsEstimated phantom iron concentrations had good correlation with true iron concentrations (1.5 T:slope = 0.86, intercept = 0.72, r(2) = 0.98; 3 T:slope = 0.85, intercept = 1.73, r(2) = 0.98). In liver, ΔB0 correlated strongly with R2* (1.5 T:r(2) = 0.86; 3 T:r(2) = 0.93) and B0-LIC had good agreement with Ferriscan-LIC (slopes/intercepts nearly 1.0/0.0, 1.5 T:r(2) = 0.67, slope = 0.93 ± 0.13, P ≈ 0.50, intercept = 1.93 ± 0.78, P ≈ 0.02; 3 T:r(2) = 0.84, slope = 1.01 ± 0.09, P ≈ 0.90, intercept = 0.23 ± 0.52, P ≈ 0.68). DISCUSSION: Fat-referenced, susceptibility-based LIC estimation is feasible at both field strengths. This approach may enable improved susceptibility mapping in the abdomen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.