ReviewWiley interdisciplinary reviews. Developmental biology
The molecular and cellular basis of gonadal sex reversal in mice and humans.
Review in Wiley interdisciplinary reviews. Developmental biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- KDM6B is a conserved activator at the top of the male sex determination pathway.Development (Cambridge, England) · 2025Article
- Postnatal Ovarian Transdifferentiation in the Absence of Estrogen Receptor Signaling Is Dependent on Genetic Background.Endocrinology · 2024Article
- The use ofSystems biology in reproductive medicine · 2023Article
- Role of p38 MAPK Signalling in Testis Development and Male Fertility.Oxidative medicine and cellular longevity · 2022Review
- MAP3K4 kinase activity dependent control of mouse gonadal sex determination†.Biology of reproduction · 2021Article
- Sexual Development of the Hermaphroditic ScallopFrontiers in cell and developmental biology · 2021Article
- Activation of stress response axis as a key process in environment-induced sex plasticity in fish.Cellular and molecular life sciences : CMLS · 2020Review
- Establishment of an organ culture system to induce Sertoli cell differentiation from undifferentiated mouse gonads.The Journal of veterinary medical science · 2020Article
- Mapping of the Sex Determining Region on Linkage Group 12 of Guppy (G3 (Bethesda, Md.) · 2019Article
- Alterations of sex determination pathways in the genital ridges of males with limited Y chromosome genes†.Biology of reproduction · 2019Article
- ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR.The Journal of biological chemistry · 2016Article
- Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium.The Journal of urology · 2016Article
- Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction.Science (New York, N.Y.) · 2016Article
- Ontogenic and morphological study of gonadal formation in genetically-modified sex reversal XY(POS) mice.The Journal of veterinary medical science · 2016Article
- Understanding sex determination in the mouse: genetics, epigenetics and the story of mutual antagonisms.Journal of genetics · 2015Review
- Sry-Independent Overexpression of Sox9 Supports Spermatogenesis and Fertility in the Mouse.Biology of reproduction · 2015Article
- Gonadal transcriptomic analysis and differentially expressed genes in the testis and ovary of the Pacific white shrimp (Litopenaeus vannamei).BMC genomics · 2015Article
- Copy number variation in the region harboring SOX9 gene in dogs with testicular/ovotesticular disorder of sex development (78,XX; SRY-negative).Scientific reports · 2015Article
- Genetic mosaics and the germ line lineage.Genes · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian gonad is adapted for the production of germ cells and is an endocrine gland that controls sexual maturation and fertility. Gonadal sex reversal, namely, the development of ovaries in an XY individual or testes in an XX, has fascinated biologists for decades. The phenomenon suggests the existence of genetic suppressors of the male and female developmental pathways and molecular genetic studies, particularly in the mouse, have revealed controlled antagonism at the core of mammalian sex determination. Both testis and ovary determination represent design solutions to a number of problems: how to generate cells with the right properties to populate the organ primordium; how to produce distinct organs from an initially bipotential primordium; how to pattern an organ when the expression of key cell fate determinants is initiated only in a discrete region of the primordium and extends to other regions asynchronously; how to coordinate the interaction between distinct cell types in time and space and stabilize the resulting morphology; and how to maintain the differentiated state of the organ throughout the adult period. Some of these, and related problems, are common to organogenesis in general; some are distinctive to gonad development. In this review, we discuss recent studies of the molecular and cellular events underlying testis and ovary development, with an emphasis on the phenomenon of gonadal sex reversal and its causes in mice and humans. Finally, we discuss sex-determining loci and disorders of sex development in humans and the future of research in this important area.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.