SynthesisEuropean radiology2013
The efficiency of acoustic radiation force impulse imaging for the staging of liver fibrosis: a meta-analysis.
Synthesis in European radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Meta-analysis: Prevalence of significant or advanced fibrosis in adults with alpha-1-antitrypsin deficiency.Alimentary pharmacology & therapeutics · 2023Pooled it
- Pooled it
- Diagnostic Accuracy of 2-Dimensional Shear Wave Elastography for the Staging of Liver Fibrosis: A Meta-analysis.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2019Pooled it
- Assessment of biopsy-proven liver fibrosis by two-dimensional shear wave elastography: An individual patient data-based meta-analysis.Hepatology (Baltimore, Md.) · 2018Pooled it
- Virtual Touch™ Quantification to Diagnose and Monitor Liver Fibrosis in Hepatitis B and Hepatitis C: A NICE Medical Technology Guidance.Applied health economics and health policy · 2017Pooled it
- Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update.Hepatology international · 2017Guideline
- Trial
- Ultrasound point shear wave elastography assessment of liver and spleen stiffness: effect of training on repeatability of measurements.European radiology · 2014Trial
- Multiparametric Ultrasound in Chronic Viral Hepatitis: From Fibrosis and Portal Hypertension to Steatosis and Focal Lesion Characterisation.Diagnostics (Basel, Switzerland) · 2026Review
- Understanding Liver and Digestive Diseases: A Paved Road to Improve Diagnosis, Management, and Treatment.Exploration of digestive diseases · 2026Article
- Longitudinal assessment of liver stiffness using ARFI technique does not support increased risk of fibrosis in rheumatoid arthritis patients on methotrexate.Journal of ultrasound · 2025Article
- Interpretable machine learning models based on shear-wave elastography radiomics for predicting cardiovascular disease in diabetic kidney disease patients.Journal of diabetes investigation · 2024Article
- Natural history study of hepatic glycogen storage disease type IV and comparison to Gbe1ys/ys model.JCI insight · 2024Article
- Nonalcoholic Fatty Liver Disease and Staging of Hepatic Fibrosis.Advances in experimental medicine and biology · 2024Review
- Real-Time Shear Wave Elastography for Determining the Ideal Site of Liver Biopsy in Diffuse Liver Disease.The Indian journal of radiology & imaging · 2024Article
- A comparison of transient elastography with acoustic radiation force impulse elastography for the assessment of liver health in patients with chronic hepatitis C: Baseline results from the TRACER study.Ultrasound (Leeds, England) · 2023Article
- High correlation of hepatic shear wave velocity with esophageal varices complication rate in patients with chronic liver diseases.BMC gastroenterology · 2023Article
- Acoustic radiation force impulse predicts long-term outcomes in a large-scale cohort: High liver cancer, low comorbidity in hepatitis B virus.World journal of gastroenterology · 2023Article
- Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and future.Clinical and molecular hepatology · 2023Review
- Ultrasound—New Techniques Are Extending the Applications.Deutsches Arzteblatt international · 2023Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAcoustic radiation force impulse (ARFI) imaging is an ultrasound-based elastography method that is integrated into a conventional ultrasound machine. A meta-analysis based on original and abstract publications was performed to evaluate the overall performance of ARFI for the diagnosis of liver fibrosis.
methodsLiterature databases and conference abstracts were searched from 2007 up to February 2012. A random effects meta-analysis of the area under the receiver operating characteristic (ROC) curve (AUROC) and the diagnostic odds ratio (DOR) was performed as well as summary ROC curve techniques. Quality analyses were conducted to assess sources of heterogeneity.
resultsThe systematic literature search revealed 36 studies, with 3,951 patients overall. The mean diagnostic accuracy of ARFI expressed as the AUROC was 0.84 (DOR, 11.54) for the diagnosis of significant fibrosis (F ≥ 2), 0.89 (DOR, 33.54) for the diagnosis of severe fibrosis (F ≥ 3) and 0.91 (DOR, 45.35) for the diagnosis of liver cirrhosis (F = 4). Subgroup analyses showed sources of heterogeneity between the different underlying liver diseases for F ≥ 3 and F = 4. The mean body mass index had a significant influence for F ≥ 2.
conclusionsThe meta-analysis revealed good diagnostic accuracy of the ARFI imaging for the staging of F ≥ 2 and F ≥ 3, and excellent diagnostic accuracy for F = 4. KEY POINTS: • Acoustic radiation force impulse (ARFI) imaging adds important information over conventional ultrasound. • ARFI imaging provides good diagnostic performance for assessing significant/severe hepatic fibrosis. • ARFI imaging shows excellent diagnostic accuracy and odds ratio for cirrhosis staging. • Body mass index significantly influences the assessment of significant fibrosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.