ArticleParasitology research2013
In vivo antimalarial activity of Trichilia megalantha harms extracts and fractions in animal models.
Article in Parasitology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Antiplasmodial, antimalarial activities and toxicity of African medicinal plants: a systematic review of literature.Malaria journal · 2021Pooled it
- Antimalarial and cytotoxic properties of Chukrasia tabularis A. Juss and Turraea vogelii Hook F. Ex. Benth.Parasitology research · 2016Article
- Assessment of in vivo antimalarial activities of some selected medicinal plants from Turkey.Parasitology research · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The crude methanol extracts of leaf, stem bark, root bark and stem bark fractions of Trichilia megalantha (Meliaceae) were screened for in vivo antimalarial activities in mice against a chloroquine resistant Plasmodium berghei berghei ANKA clone using the 4-day suppressive test procedure. Chloroquine diphosphate was used as the positive control. The extracts demonstrated intrinsic antimalarial property. Of all the seven extracts studied, the stem bark gave the highest activity. At 200 mg/kg of mouse, the stem bark extract had complete suppression of parasite growth (100%). Least activity was observed for the leaf extract, while the root bark had a parasite suppression of 98.4% at 800 mg/kg comparable to that of Chloroquine. Percentage suppression of parasite growth on day 4 post-infection ranged from 3.1 to 96.1% in mice infected with P. berghei and treated with extracts and fractions of T. megalantha when compared with chloroquine diphosphate, the standard reference drug which had a chemosuppression of 96.2%. At 400 mg/kg, the stem bark chloroform fraction was the most active fraction with 89.1% parasite growth suppression followed by the ethyl acetate fraction (76.4%), hexane soluble fraction (54.8%) and methanol fraction (20.5%). The mean survival time of mice that received extract ranged from 8.75 ± 0.65 to 26.0 ± 1.2 days (increased as the dose increases to 800 mg/kg), which was statistically significant, except the lowest dose (100 mg/kg) compared to the negative control group mice (9.45 ± 0.6 days). The animals that were treated with Chloroquine had mean survival time of 23.5 ± 1.2 days.
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