ArticleBreast cancer research and treatment2013
Breast cancer characteristics and HIV among 1,092 women in Soweto, South Africa.
Article in Breast cancer research and treatment, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Epidemiology and clinical characteristics of breast cancer in Ethiopia: a systematic review.BMC cancer · 2024Pooled it
- Cost of chemotherapy-related care for breast cancer care: evidence and implications from a provider perspective at a public tertiary hospital in South Africa.Health economics review · 2026Article
- Advanced Metastatic Bilateral Breast Carcinoma in a Pregnant Woman With HIV During the Second Trimester: A Rare Case Report and Review of the Current Literature.Clinical case reports · 2025Article
- Breast carcinoma tumour-infiltrating lymphocytes in pre- and post-systemic therapy in HIV-positive and HIV-negative women.Southern African journal of HIV medicine · 2025Article
- Female breast cancer trends: A South African perspective.SA journal of radiology · 2025Article
- The association of HIV status with triple-negative breast cancer in patients with breast cancer in South Africa: a cross-sectional analysis of case-only data from a prospective cohort study.The Lancet. Global health · 2024Article
- Navigating the Nexus: HIV and Breast Cancer-A Critical Review.International journal of molecular sciences · 2024Review
- Gynaecologic and breast cancers in women living with HIV in South Africa: A record linkage study.International journal of cancer · 2024Article
- Breast cancer in women by HIV status: A report from the South African National Cancer Registry.PloS one · 2024Article
- Characterizing HIV status documentation among cancer patients at regional cancer centers in Malawi, Zimbabwe, and South Africa.Infectious agents and cancer · 2023Article
- PAM50 intrinsic subtypes, risk of recurrence score and breast cancer survival in HIV-positive and HIV-negative patients-a South African cohort study.Breast cancer research and treatment · 2023Article
- Preoperative Biomarkers and Survival in Chinese Breast Cancer Patients with HIV: A Propensity-Score-Matched-Cohort Study.Viruses · 2023Article
- Survival Disparities Between Patients with Breast Cancer With and Without HIV: A Research Framework.JCO global oncology · 2023Article
- Virologic Nonsuppression Among Patients With HIV Newly Diagnosed With Cancer at Uganda Cancer Institute: A Cross-Sectional Study.JCO global oncology · 2023Article
- HIV Prevalence and Characteristics Among Patients With AIDS-Defining and Non-AIDS-Defining Cancers in a Tertiary Hospital in Kenya.JCO global oncology · 2023Article
- Risk factors for breast cancer among women in Ekurhuleni Metropolitan Municipality, Gauteng province of South Africa, 2017‒2020: a case-control study.Ecancermedicalscience · 2023Article
- Epidemiology of Breast Cancer Presentation in Botswana, South Africa, and the United States.The Journal of surgical research · 2022Article
- Disparities in breast cancer survival between women with and without HIV across sub-Saharan Africa (ABC-DO): a prospective, cohort study.The lancet. HIV · 2022Article
- Pharmacogenetics of Breast Cancer Treatments: A Sub-Saharan Africa Perspective.Pharmacogenomics and personalized medicine · 2022Review
- Impact of HIV infection on overall survival among women with stage IV breast cancer in South Africa.Breast cancer research and treatment · 2021Article
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
In the low-income HIV-endemic regions of sub-Saharan Africa, malignancies related to HIV have long been recognized as a major public health problem. However, epithelial malignancies associated with older age, such as breast cancer, are also rising dramatically in those regions. We compared consecutive HIV-positive and -negative black women diagnosed with breast cancer at a large public hospital in Soweto, South Africa, on age, year of diagnosis, stage, grade, and receptor status, and grouped HIV-positive patients by CD4 cell counts. We computed prevalence ratios of the associations of HIV status and CD4 category with stage, grade, receptor status, and among the HIV-positive patients, receipt of ART, controlling for age and year of diagnosis. Of 1,092 patients, 765 were tested for HIV; 151 (19.7 %) tested positive, a prevalence similar to that in the source population. Although, HIV-positive patients were younger than HIV-negative patients (p < 0.001), HIV status was not associated with the tumor characteristics. Thirty-seven women (25.9 %) had CD4 cell counts <200 cells/μl. Patients in that severely immunocompromised group were older than those in the other groups (p = 0.01). This study is the first to analyze the association of HIV with breast cancer in a large sample. Based on similar HIV prevalence in our sample and the population of the hospital's catchment area, clinicians serving HIV-endemic communities should promote routine HIV testing of younger breast cancer patients and immediate treatment of those who test positive, prior to the initiation of chemotherapy. Research is needed on treatment and outcomes given HIV and low CD4 cell count.
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