SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2013
Glutathione S-transferase M1 null genotype is associated with increased risk of oral cancer in East Asians: a meta-analysis.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between glutathione S-transferase M1 (GSTM1) null genotype and risk of oral cancer in East Asians is uncertain owing to the inconclusive results from published studies. In the present study, we performed a meta-analysis of 12 studies from three East Asian countries (China, Japan, and Korea). Those 12 studies consisted of 1,718 cases and 2,236 controls. The pooled odds ratio (OR) and corresponding 95 % confidence interval (95 %CI) were calculated to assess the relationship. Overall, the meta-analysis showed that GSTM1 null genotype was associated with increased risk of oral cancer in East Asians (OR = 1.48, 95 %CI = 1.09-2.00, P = 0.011). The results of the cumulative meta-analysis further identified the significant association above. Subgroup analysis by countries showed that the association was still significant in Japan (OR = 1.56, 95 %CI = 1.10-2.22, P = 0.012), but not in China (OR = 1.35, 95 %CI = 0.68-2.68, P = 0.393) and Korea (OR = 1.35, 95 %CI = 0.79-2.32, P = 0.271). In conclusion, the meta-analysis suggests that GSTM1 null genotype is associated with increased risk of oral cancer in East Asians. Further studies are needed to provide new and comprehensive assessments on the association in China and Korea.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.