Evidence map›Paper›PMID 23801097›Full record

ReviewEuropean journal of clinical nutrition2013

Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets.

A Paoli, A Rubini, J S Volek, K A Grimaldi

Erratum issued 5 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of clinical nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 5 registered trials, which are not on this map. Cited by 386 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
386citing papers in PubMed, 21 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03691558 nacompletednot on this mapstarted 2017, after this paper: background citation

Effects of Five Weeks of Ketogenic Diet on Long Distance Triathletes Performance

TypeinterventionalSponsorUniversity of PadovaRan2017 to 2017Enrolled16ConditionsKetogenic Dieting, Physical ActivityArmsKetogenic diet, Western Diet
NCT04163120 nacompletednot on this mapstarted 2017, after this paper: background citation

Effects of a Low Calorie Mediterranean Ketogenic Diet in Women With Polycystic Ovary Syndrome

TypeinterventionalSponsorUniversity of PadovaRan2017 to 2017Enrolled14ConditionsPolycystic Ovary SyndromeArmsLow calorie Mediterranean ketogenic diet with phytoextracts (KEMEPHY)
NCT05119010 naterminatednot on this mapstarted 2023, after this paper: background citation

A Pilot Study Evaluating a Ketogenic Diet Concomitant to Nivolumab and Ipilimumab in Patients With Metastatic Renal Cell Carcinoma

TypeinterventionalSponsorGustave Roussy, Cancer Campus, Grand ParisRan2023 to 2024Enrolled3ConditionsMetastatic Renal Cell CarcinomaArmsContinuous ketogenic diet, Discontinuous ketogenic diet, beta-hydroxybutyrate (BHB) supplementation
NCT05219006 nacompletednot on this mapstarted 2021, after this paper: background citation

Ketogenic Diet Effects on the Frequency of Non Epileptic Seizures in Patients With Dissociative Neurological Symptom Disorder: a Pilot Study

TypeinterventionalSponsorEl Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco SuarezRan2021 to 2023Enrolled17ConditionsNon Epileptic Seizures, Functional Neurological Symptom Disorder, Conversion Disorder, Ketogenic DietingArmsketogenic dieting, healthy dieting
NCT05558488 nacompletednot on this mapstarted 2019, after this paper: background citation

Effect of a Meatless,Ketogenic Restrictive Diet on Body Composition, Concentration of Trimethylamine N-Oxide (TMAO),Ketone Bodies and Glucose in Blood and Urine, Somatic Disorders, Strength Capacity, Oxidative Stress, Immune Response

TypeinterventionalSponsorKatarzyna SiedzikRan2019 to 2022Enrolled14ConditionsBody Weight, Oxidative Stress, Trimethylamine N-oxide, Immunologic FactorsArmsMeatless, restrictive ketogenic diet
3 · Its place in the literature

Who cites it

386 citing papers in PubMed, 21 syntheses or guidelines pooled it, 875 citations in OpenAlex.

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326 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

A PaoliThe Physiological Laboratory, Department of Biomedical Sciences, University of Padova, Padova, Italy. antonio.paoli@unipd.it
A Rubini
J S Volek
K A Grimaldi
University of Padua · ITNational Technical University of Athens · GRUniversity of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Very-low-carbohydrate diets or ketogenic diets have been in use since the 1920s as a therapy for epilepsy and can, in some cases, completely remove the need for medication. From the 1960s onwards they have become widely known as one of the most common methods for obesity treatment. Recent work over the last decade or so has provided evidence of the therapeutic potential of ketogenic diets in many pathological conditions, such as diabetes, polycystic ovary syndrome, acne, neurological diseases, cancer and the amelioration of respiratory and cardiovascular disease risk factors. The possibility that modifying food intake can be useful for reducing or eliminating pharmaceutical methods of treatment, which are often lifelong with significant side effects, calls for serious investigation. This review revisits the meaning of physiological ketosis in the light of this evidence and considers possible mechanisms for the therapeutic actions of the ketogenic diet on different diseases. The present review also questions whether there are still some preconceived ideas about ketogenic diets, which may be presenting unnecessary barriers to their use as therapeutic tools in the physician's hand.

Indexed as

Diet, Carbohydrate-RestrictedDiet, KetogenicKetosisCardiovascular DiseasesDietary CarbohydratesDiet, ReducingGlucoseHumansMetabolic DiseasesNeoplasmsNervous System DiseasesObesityWeight LossDietary CarbohydratesGlucose

Identifiers

PMID23801097
PMCPMC3826507
OpenAlexW2125222784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.