Evidence map›Paper›PMID 23800984›Full record

Trial reportJournal of anesthesia2014

Comparison between intranasal dexmedetomidine and intranasal ketamine as premedication for procedural sedation in children undergoing MRI: a double-blind, randomized, placebo-controlled trial.

Prakhar Gyanesh, Rudrashish Haldar, Divya Srivastava, Prashant Mohan Agrawal, Akhilesh Kumar Tiwari, P K Singh

2 registry-linked trialsAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of anesthesia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02299232 phase4completednot on this map

Comparison of Two Different Intranasal Doses of Dexmedetomidine in Children for Magnetic Resonance Imaging (MRI) Sedation

TypeinterventionalSponsorSisli Hamidiye Etfal Training and Research HospitalRan2014 to 2014Enrolled60ConditionsAnesthesiaArmsDexmedetomidine
NCT05934669 phase4recruitingnot on this mapstarted 2023, after this paper: background citation

Randomized Controlled Trial of Intranasal (IN) Midazolam vs IN Dexmedetomidine vs IN Ketamine Evaluating Length of Stay After Medication Administration and Anxiolysis During Minimal Procedures in Pediatric Population in Pediatric Emergency Department

TypeinterventionalSponsorUniversity of OklahomaRan2023 to 2025Enrolled90ConditionsLaceration of Skin, Anxiety, Discharge TimeArmsIntranasal Midazolam, Intranasal Dexmedetomidine, Intranasal Ketamine
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Prakhar GyaneshDepartment of Neuroanaesthesia and Neurocritical Care, Global Hospital, Chennai, India, prakhargyan@gmail.com.
Rudrashish Haldar
Divya Srivastava
Prashant Mohan Agrawal
Akhilesh Kumar Tiwari
P K Singh
Sanjay Gandhi Post Graduate Institute of Medical Sciences · INGlobal Hospitals · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionProviding anesthesia to children undergoing MRI is challenging. Adequate premedication, administered noninvasively, would make the process smoother. In this study, we compare the efficacy of intranasal dexmedetomidine (DXM) with the intranasal administration of ketamine for procedural sedation in children undergoing MRI.

methodsWe studied 150 children, between 1 and 10 years of age, divided randomly into three groups (DXM, K, and S). For blinding, every child received the intranasal drugs twice; syringe S1, 60 min before, and syringe S2, 30 min before intravenous (IV) cannulation. For children in group DXM, S1 contained DXM (1 μg/kg) and S2 was plain saline. Children in group K received saline in S1 and ketamine (5 mg/kg) in S2 whereas children in group S received saline in both S1 and S2. The child's response to drug administration, ease of IV cannulation, the satisfaction of the anesthesiologist and child's parents with the premedication, and the total propofol dose required for the satisfactory conduct of the procedure were compared. We also compared the time to awakening and discharge of the child as well as the occurrence of any side effects with these drugs.

resultsBoth DXM and ketamine were equally effective as premedication in these patients. Most of the children accepted the intranasal drugs with minimal discomfort; 90.4 % of the anesthesiologists in the DXM group and 82.7 % in the ketamine group were satisfied with the conditions for IV cannulation whereas only 21.3 % were satisfied in the saline group. The total dose of propofol used was less in the study groups. Furthermore, children in group DXM and group K had earlier awakening and discharge than those in group S.

conclusionDXM and ketamine were equally effective, by the intranasal route, as premedication in children undergoing MRI.

Indexed as

Administration, IntranasalAnalgesicsChildChild, PreschoolDexmedetomidineDouble-Blind MethodFemaleHumansHypnotics and SedativesInfantKetamineMagnetic Resonance ImagingMalePremedicationAnalgesicsDexmedetomidineHypnotics and SedativesKetamine

Identifiers

PMID23800984
OpenAlexW2031959675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.