ArticleNature communications2013
Sublinear binocular integration preserves orientation selectivity in mouse visual cortex.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Eye-specific drive and binocular suppression in mouse visual cortex during critical period development.bioRxiv : the preprint server for biology · 2026Article
- Continuous flash suppression responses in mouse visual cortex: Stimulus laterality and anesthesia effects.iScience · 2026Article
- Behavioural states control binocular vision through input-specific mechanisms.Nature communications · 2026Article
- Binocular Circuitry as a Model for Understanding Experience-Dependent Circuit Development across the Mammalian Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Circuit dynamics of binocular conflict in mouse primary visual cortex.Frontiers in systems neuroscience · 2026Article
- Responses to conflicting binocular stimuli in mouse primary visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Layer 6 corticocortical neurons are a major route for intra- and interhemispheric feedback.eLife · 2025Article
- A role for ocular dominance in binocular integration.Current biology : CB · 2023Article
- Interactions between rodent visual and spatial systems during navigation.Nature reviews. Neuroscience · 2023Review
- Binocular visual experience drives the maturation of response variability and reliability in the visual cortex.iScience · 2022Article
- Article
- A binocular synaptic network supports interocular response alignment in visual cortical neurons.Neuron · 2022Article
- A Distinct Population of L6 Neurons in Mouse V1 Mediate Cross-Callosal Communication.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex.Neuron · 2021Article
- Impact of visual callosal pathway is dependent upon ipsilateral thalamus.Nature communications · 2020Article
- Development and binocular matching of orientation selectivity in visual cortex: a computational model.Journal of neurophysiology · 2020Article
- Long-term Monocular Deprivation during Juvenile Critical Period Disrupts Binocular Integration in Mouse Visual Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Article
- Persistent Sodium Current Mediates the Steep Voltage Dependence of Spatial Coding in Hippocampal Pyramidal Neurons.Neuron · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Inputs from the two eyes are first combined in simple cells in the primary visual cortex. Consequently, visual cortical neurons need to have the flexibility to encode visual features under both monocular and binocular situations. Here we show that binocular orientation selectivity of mouse simple cells is nearly identical to monocular orientation selectivity in both anaesthetized and awake conditions. In vivo whole-cell recordings reveal that the binocular integration of membrane potential responses is sublinear. The sublinear integration keeps binocularly evoked depolarizations below threshold at non-preferred orientations, thus preserving orientation selectivity. Computational simulations based on measured synaptic conductances indicate that inhibition promotes sublinear binocular integration, which are further confirmed by experiments using genetic and pharmacological manipulations. Our findings therefore reveal a cellular mechanism for how visual system can switch effortlessly between monocular and binocular conditions. The same mechanism may apply to other sensory systems that also integrate multiple channels of inputs.
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Registered trials
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