ArticleNeuroImage2013
The EEG correlates of the TMS-induced EMG silent period in humans.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 4 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Methodological Choices Matter: A Systematic Comparison of TMS-EEG Studies Targeting the Primary Motor Cortex.Human brain mapping · 2024Pooled it
- Resting and TMS-EEG markers of treatment response in major depressive disorder: A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Transcranial magnetic stimulation neurophysiology of patients with major depressive disorder: a systematic review and meta-analysis.Psychological medicine · 2021Pooled it
- Cerebral Cortical Activity Following Non-invasive Cerebellar Stimulation-a Systematic Review of Combined TMS and EEG Studies.Cerebellum (London, England) · 2020Pooled it
- Alleviation of ADHD symptoms by non-invasive right prefrontal stimulation is correlated with EEG activity.NeuroImage. Clinical · 2020Trial
- Lamotrigine and levetiracetam exert a similar modulation of TMS-evoked EEG potentials.Epilepsia · 2017Trial
- Theta Burst Stimulation of the Cerebellum Modifies the TMS-Evoked N100 Potential, a Marker of GABA Inhibition.PloS one · 2015Trial
- TMS-EEG signatures of GABAergic neurotransmission in the human cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Mechanisms of transcranial magnetic brain stimulation.Physiological reviews · 2026Review
- Article
- Complexity of resting cortical activity predicts neurophysiological responses to theta-burst stimulation but fails to generalize: A rigorous machine-learning approach.PLoS computational biology · 2026Article
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Complexity of Resting Cortical Activity Predicts Neurophysiological Responses to Theta- Burst Stimulation but Fails to Generalize: A Rigorous Machine-Learning Approach.Research square · 2025Article
- A feasibility study of sequenced TMS and TBS dosing in adolescents with major depressive disorder.Transcranial magnetic stimulation (2024) · 2025Article
- Stimulation Parameters Recruit Distinct Cortico-Cortical Pathways: Insights from Microstate Analysis on TMS-Evoked Potentials.Brain topography · 2025Article
- Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program.Frontiers in psychiatry · 2025Article
- Article
- Differential analgesic effects of high-frequency or accelerated intermittent theta burst stimulation of M1 on experimental tonic pain: Correlations with cortical activity changes assessed by TMS-EEG.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Article
- Water and brain function: effects of hydration status on neurostimulation with transcranial magnetic stimulation.Journal of neurophysiology · 2024Article
- Neuromodulation for Cannabis Use: A Scoping Review.Brain sciences · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 5 countries.
Funding
Abstract
Application of magnetic or electrical stimulation to the motor cortex can result in a period of electromyography (EMG) silence in a tonically active peripheral muscle. This period of EMG silence is referred to as the silent period (SP). The duration of SP shows intersubject variability and reflects the integrity of cortical and corticospinal pathways. A non-invasive technique for assessing the duration of SP is the combination of Transcranial Magnetic Stimulation (TMS) with EMG. Utilizing TMS-EMG, several studies have reported on the shortening or lengthening of SP in neuropsychiatric disorders such as schizophrenia, bipolar disorder, depression, obsessive compulsive disorder, epilepsy, Parkinson's disease, and stroke. However, cortical, corticospinal and peripheral components are difficult to disentangle from EMG alone. Here, we use the multimodal neuroimaging technique of TMS-EMG combined with concurrent electroencephalography (EEG) recording to further examine the cortical origin of SP and the cortical oscillatory activity that underlies SP genesis. We demonstrate that the duration of SP is related to the temporal characteristics of the cortical reactivity and the power of delta to alpha oscillations in both local and remote areas ipsilateral and contralateral to the stimulation site, and beta oscillations locally. We illustrate that, compared to EMG, the EEG indices of the SP provide additional information about the brain dynamics and propose that the EEG measures of SP may be used in future clinical and research investigations to more precisely delineate the mechanisms underlying inhibitory impairments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.