ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2013
Arsenic exposure and cancer mortality in a US-based prospective cohort: the strong heart study.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 104 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
104 citing papers in PubMed, 4 syntheses or guidelines pooled it, 206 citations in OpenAlex.
- Environmental Nonessential Element Exposure and Urologic Cancer: A Systematic Review and Meta-Analysis.JAMA network open · 2026Pooled it
- Hazardous Environmental Pollutants and Cancer Disparities: A Systematic Review on the Consideration of Race and Ethnicity in Environmental Epidemiology Research.Current environmental health reports · 2025Pooled it
- Use of study-specific MOE-like estimates to prioritize health effects from chemical exposure for analysis in human health assessments.Environment international · 2020Pooled it
- A Systematic Review and Meta-Regression Analysis of Lung Cancer Risk and Inorganic Arsenic in Drinking Water.International journal of environmental research and public health · 2015Pooled it
- Effect of an Arsenic Mitigation Program on Arsenic Exposure in American Indian Communities: A Cluster Randomized Controlled Trial of the Community-Led Strong Heart Water Study Program.Environmental health perspectives · 2024Trial
- Behavioral determinants of arsenic-safe water use among Great Plains Indian Nation private well users: results from the Community-Led Strong Heart Water Study Arsenic Mitigation Program.Environmental health : a global access science source · 2023Trial
- Evaluation of a water arsenic filter in a participatory intervention to reduce arsenic exposure in American Indian communities: The Strong Heart Water Study.The Science of the total environment · 2023Trial
- Cure or Suppression.Integrative medicine (Encinitas, Calif.) · 2026Article
- Chronic inorganic arsenic exposure impairs locomotor performance and socio-affective behavior in zebrafish.Biomolecules & biomedicine · 2026Article
- Dietary Spirulina Ameliorates Arsenic-Induced Toxicity in Nile Tilapia, Oreochromis niloticus.Veterinary medicine and science · 2026Article
- Exploring the Influence of Chemical Exposures in Breast Cancer Disparities: High-Throughput Transcriptomic Analysis in Normal Breast Cells from Diverse Donors.bioRxiv : the preprint server for biology · 2026Article
- Strong Heart, Strong Smile: Tooth Loss and Incidence of CVD in American Indian Populations.Community dentistry and oral epidemiology · 2026Article
- Association between meat consumption and cancer mortality in Korean adults.Frontiers in nutrition · 2026Article
- Arsenic in Drinking Water and Prostate Cancer: A Population-Based Case-Control Study in Northern Chile.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Arsenic in drinking water and breast cancer: a case-control study from a high exposure area in Northern Chile.Breast cancer research and treatment · 2025Article
- Current Research in Drug-Free Cancer Therapies.Bioengineering (Basel, Switzerland) · 2025Review
- Article
- The modifying effect of dietary index for gut microbiota on the association between urinary arsenic exposure and bladder cancer risk: a nationwide cohort study.Frontiers in nutrition · 2025Article
- Trace Element Concentrations of Arsenic and Selenium in Toenails and Risk of Prostate Cancer among Pesticide Applicators.Current oncology (Toronto, Ont.) · 2024Article
- Impact of Droughts on Served Drinking Water Disparities in California, 2007-2020.American journal of public health · 2024Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundInorganic arsenic, a carcinogen at high exposure levels, is a major global health problem. Prospective studies on carcinogenic effects at low-moderate arsenic levels are lacking.
methodsWe evaluated the association between baseline arsenic exposure and cancer mortality in 3,932 American Indians, 45 to 74 years of age, from Arizona, Oklahoma, and North/South Dakota who participated in the Strong Heart Study from 1989 to 1991 and were followed through 2008. We estimated inorganic arsenic exposure as the sum of inorganic and methylated species in urine. Cancer deaths (386 overall, 78 lung, 34 liver, 18 prostate, 26 kidney, 24 esophagus/stomach, 25 pancreas, 32 colon/rectal, 26 breast, and 40 lymphatic/hematopoietic) were assessed by mortality surveillance reviews. We hypothesized an association with lung, liver, prostate, and kidney cancers.
resultsMedian (interquartile range) urine concentration for inorganic plus methylated arsenic species was 9.7 (5.8-15.6) μg/g creatinine. The adjusted HRs [95% confidence interval (CI)] comparing the 80th versus 20th percentiles of arsenic were 1.14 (0.92-1.41) for overall cancer, 1.56 (1.02-2.39) for lung cancer, 1.34 (0.66, 2.72) for liver cancer, 3.30 (1.28-8.48) for prostate cancer, and 0.44 (0.14, 1.14) for kidney cancer. The corresponding hazard ratios were 2.46 (1.09-5.58) for pancreatic cancer, and 0.46 (0.22-0.96) for lymphatic and hematopoietic cancers. Arsenic was not associated with cancers of the esophagus and stomach, colon and rectum, and breast.
conclusionsLow to moderate exposure to inorganic arsenic was prospectively associated with increased mortality for cancers of the lung, prostate, and pancreas. IMPACT: These findings support the role of low-moderate arsenic exposure in development of lung, prostate, and pancreas cancer and can inform arsenic risk assessment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.