ArticleDevelopmental biology2013
Size-dependent regulation of dorsal-ventral patterning in the early Drosophila embryo.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Embryonic scaling: morphogen gradients, size sensing, and scaler genes.Frontiers in cell and developmental biology · 2026Review
- Article
- A toolkit for mapping cell identities in relation to neighbors reveals conserved patterning of neuromesodermal progenitor populations.PLoS biology · 2025Article
- The proximal enhancer of the snail gene mediates negative autoregulatory feedback in Drosophila melanogaster.Genetics · 2025Article
- Target gene responses differ when transcription factor levels are acutely decreased by nuclear export versus degradation.Development (Cambridge, England) · 2024Article
- Target gene responses differ when transcription factor levels are acutely decreased by nuclear export versus degradation.bioRxiv : the preprint server for biology · 2024Article
- Single-cell transcriptomics illuminates regulatory steps driving anterior-posterior patterning of Drosophila embryonic mesoderm.Cell reports · 2023Article
- The nested embryonic dorsal domains of BMP-target genes are not scaled to size during the evolution of Drosophila species.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
- Dynamic patterning by morphogens illuminated by cis-regulatory studies.Development (Cambridge, England) · 2021Review
- Integrating cellular dimensions with cell differentiation during early development.Current opinion in cell biology · 2020Review
- Mechanism and implications of morphogen shuttling: Lessons learned from dorsal and Cactus in Drosophila.Developmental biology · 2020Article
- Robustness of the Dorsal morphogen gradient with respect to morphogen dosage.PLoS computational biology · 2020Article
- Scale-invariant patterning by size-dependent inhibition of Nodal signalling.Nature cell biology · 2018Article
- Article
- Modeling of the dorsal gradient across species reveals interaction between embryo morphology and Toll signaling pathway during evolution.PLoS computational biology · 2014Article
- Adaptation of the length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large Drosophila melanogaster embryos.Development (Cambridge, England) · 2014Article
- Studies of morphogens: keep calm and carry on.Development (Cambridge, England) · 2013Article
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4 authors.
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Abstract
How natural variation in embryo size affects patterning of the Drosophila embryo dorsal-ventral (DV) axis is not known. Here we examined quantitatively the relationship between nuclear distribution of the Dorsal transcription factor, boundary positions for several target genes, and DV axis length. Data were obtained from embryos of a wild-type background as well as from mutant lines inbred to size select embryos of smaller or larger sizes. Our data show that the width of the nuclear Dorsal gradient correlates with DV axis length. In turn, for some genes expressed along the DV axis, the boundary positions correlate closely with nuclear Dorsal levels and with DV axis length; while the expression pattern of others is relatively constant and independent of the width of the Dorsal gradient. In particular, the patterns of snail (sna) and ventral nervous system defective (vnd) correlate with nuclear Dorsal levels and exhibit scaling to DV length; while the pattern of intermediate neuroblasts defective (ind) remains relatively constant with respect to changes in Dorsal and DV length. However, in mutants that exhibit an abnormal expansion of the Dorsal gradient which fails to scale to DV length, only sna follows the Dorsal distribution and exhibits overexpansion; in contrast, vnd and ind do not overexpand suggesting some additional mechanism acts to refine the dorsal boundaries of these two genes. Thus, our results argue against the idea that the Dorsal gradient works as a global system of relative coordinates along the DV axis and suggest that individual targets respond to changes in embryo size in a gene-specific manner.
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