ArticleReproductive sciences (Thousand Oaks, Calif.)2014
Reproductive function of the male obese Zucker rats: alteration in sperm production and sperm DNA damage.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Effects of Trazodone on Testicular Morphology, Sperm Parameters and Contractility of the Distal Cauda Epididymal Duct in Rats.Basic & clinical pharmacology & toxicology · 2026Article
- Protective Effects ofLife (Basel, Switzerland) · 2025Article
- High-Fat Diets Disturb Rat Epididymal Sperm Maturation.International journal of molecular sciences · 2025Article
- Obesity Alters POMC and Kisspeptin Neuron Cross Talk Leading to Reduced Luteinizing Hormone in Male Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Protective Effect of Black Rice Cyanidin-3-Glucoside on Testicular Damage in STZ-Induced Type 1 Diabetic Rats.Foods (Basel, Switzerland) · 2024Article
- Single-Cell Transcriptomics Identifies Pituitary Gland Changes in Diet-Induced Obesity in Male Mice.Endocrinology · 2024Article
- DetectingHeliyon · 2023Article
- Quercetin Ameliorates Testicular Damage in Zucker Diabetic Fatty Rats through Its Antioxidant, Anti-Inflammatory and Anti-Apoptotic Properties.International journal of molecular sciences · 2022Article
- Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models.Nature communications · 2022Article
- Pnpla5-knockout rats exhibit reduced expression levels of proteins involved in steroid metabolism and wound healing compared to wild-type rats.BMC genomics · 2022Article
- Regulation of male sex hormones strongly heightens copulation behavior indices in rat's model administeredAfrican health sciences · 2022Article
- Effect of Chronic Moderate Caloric Restriction on the Reproductive Function in Aged Male Wistar Rats.Nutrients · 2022Article
- Characterization of the structural, oxidative, and immunological features of testis tissue from Zucker diabetic fatty rats.Open life sciences · 2022Article
- Sexually Dimorphic Response of Increasing Dietary Intake of High Amylose Wheat on Metabolic and Reproductive Outcomes in Male and Female Mice.Nutrients · 2019Article
- Obesity, Neuroinflammation, and Reproductive Function.Endocrinology · 2019Review
- Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Intermittent resistance exercise and obesity, considered separately or combined, impair spermatic parameters in adult male Wistar rats.International journal of experimental pathology · 2018Article
- Adipokines in Semen: Physiopathology and Effects on Spermatozoas.International journal of endocrinology · 2018Review
- Resveratrol attenuates reproductive alterations in type 1 diabetes-induced rats.International journal of experimental pathology · 2017Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity has been considered a public health issue in many countries and is of increasing concern for authorities over the past 6 years. The Zucker rat is a good experimental model for obesity and diabetes studies due to its metabolic characteristics that are similar to those developed by humans. A total of 12 obese Zucker rats and their lean littermates were killed in pubertal and young adult phases for assessing organ weights (testis and epididymis), testicular histomorphometric and stereological analyses, daily sperm production, and transit time in the epididymis. Sperm integrity was also investigated in the adult animals using the Comet assay. Alterations in organ weights, seminiferous epithelium architecture, sperm production, and transit time were noticed in the pubertal fatty rats. The volume density of the lymphatic space was decreased in both the ages. Adult animals had a significant increase in the extent of damage found in sperm DNA. Our results show for the first time that leptin receptor deficiency compromises sperm production during puberty and that genetic obese Zucker rats have increased sperm DNA fragmentation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.