ArticleCardiovascular diabetology2013
Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus.
Article in Cardiovascular diabetology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Pooled it
- Clinical Significance of Arterial Stiffness and Thickness Biomarkers in Type 2 Diabetes Mellitus: An Up-To-Date Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Flow-mediated-paradoxical vasoconstriction is independently associated with asymptomatic myocardial ischemia and coronary artery disease in type 2 diabetic patients.Cardiovascular diabetology · 2014Trial
- Impaired Kidney Function, Subclinical Myocardial Injury, and Their Joint Associations with Cardiovascular Mortality in the General Population.Journal of clinical medicine · 2025Article
- Carotid Resistance and Pulsatility: Non-Invasive Markers for Diabetes Mellitus-Related Vascular Diseases.Journal of clinical medicine · 2025Article
- Cardiac Troponin Serum Concentration Measurement Is Useful Not Only in the Diagnosis of Acute Cardiovascular Events.Journal of personalized medicine · 2024Review
- Long-Term Maternal Metabolic and Cardiovascular Phenotypes after a Pregnancy Complicated by Mild Gestational Diabetes Mellitus or Obesity.American journal of perinatology · 2023Observational
- Assessing the risk factors for myocardial infarction in diet-induced prediabetes: myocardial tissue changes.BMC cardiovascular disorders · 2022Article
- Elevation Mechanisms and Diagnostic Consideration of Cardiac Troponins under Conditions Not Associated with Myocardial Infarction. Part 2.Life (Basel, Switzerland) · 2021Review
- Association of monocyte-to-high density lipoprotein ratio with arterial stiffness in patients with diabetes.BMC cardiovascular disorders · 2021Article
- Predicting Long-Term Absence of Coronary Artery Calcium in Metabolic Syndrome and Diabetes: The MESA Study.JACC. Cardiovascular imaging · 2021Article
- Cardiovascular events prediction by left ventricular longitudinal strain and serum high-sensitivity troponin I in patients with axial spondyloarthritis.Clinical rheumatology · 2020Article
- Carotid artery stiffness in rural adult Chinese: a cross-sectional analysis of the community-based China stroke cohort study.BMJ open · 2020Article
- Plasma metabolites associated with arterial stiffness in patients with type 2 diabetes.Cardiovascular diabetology · 2020Article
- Putative functional non-coding polymorphisms in SELP significantly modulate sP-selectin levels, arterial stiffness and type 2 diabetes mellitus susceptibility.BMC endocrine disorders · 2020Article
- Performance of the ESC 0/1-h and 0/3-h Algorithm for the Rapid Identification of Myocardial Infarction Without ST-Elevation in Patients With Diabetes.Diabetes care · 2020Article
- Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study.Atherosclerosis · 2016Article
- Early Cellular Changes in the Ascending Aorta and Myocardium in a Swine Model of Metabolic Syndrome.PloS one · 2016Article
- High-Sensitivity Cardiac Troponin T and Risk of Hypertension.Circulation · 2015Observational
- Cardio-ankle vascular index is associated with cardiovascular target organ damage and vascular structure and function in patients with diabetes or metabolic syndrome, LOD-DIABETES study: a case series report.Cardiovascular diabetology · 2015Observational
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveType 2 diabetes mellitus (T2DM) is associated with subclinical myocardial injury although the underlying mechanism is uncertain. We postulated that arterial stiffness, endothelial dysfunction and subclinical atherosclerosis may contribute to subclinical myocardial injury in patients with T2DM.
methodsSerum high-sensitivity troponin I (hs-TNI) an indicator of myocardial injury, was measured in 100 patients with T2DM without clinical evidence of macrovascular disease and 150 age and gender-matched controls. Elevated hs-TnI was defined as follow (derived from the 99th percentile from controls): Male >11.1 ng/L; female >7.6 ng/L. Measures that may contribute to myocardial damage in patients with T2DM, including brachial-ankle pulse wave velocity (ba-PWV), brachial flow mediated dilatation (FMD) and carotid intima media thickness (IMT), were also assessed.
resultsThe serum level of hs-TNI (5.7 ± 9.2 μg/L vs. 3.2 ± 1.9 μg/L, P< 0.01) and the prevalence of elevated hs-TNI (12% vs. 4%, P = 0.02) were significantly higher in patients with T2DM than controls. Patients with T2DM also had significantly worse ba-PWV (17.98 ± 3.91ms-1 vs. 15.70 ± 2.96 ms-1), brachial FMD (2.6 ± 3.5% vs. 5.5 ± 4.2%, P< 0.01) and carotid IMT (0.96 ± 0.20 mm vs. 0.86 ± 0.14 mm, P< 0.01). In patients with T2DM, hs-TNI was positively correlated with systolic blood pressure (r = 0.31, P<0.01), serum creatinine (r = 0.26, P = 0.01) and ba-PWV (r = 0.34, P< 0.01). Importantly, multiple regression revealed that only ba-PWV was independently associated with hs-TNI (β = 0.25, P = 0.04).
conclusionThe results demonstrated an independent association between ba-PWV and hs-TNI in patients with T2DM with no clinical evidence of macrovascular disease. These findings suggest that increased arterial stiffness is closely related to subclinical myocardial injury in patients with T2DM.
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Registered trials
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