Evidence map›Paper›PMID 23799674›Full record

ArticleJournal of primary care & community health2013

Evaluation of fecal immunochemical tests for colorectal cancer screening.

Jeanette M Daly, Camden P Bay, Barcey T Levy

Abstract readEvaluation Study
In one paragraph

Article in Journal of primary care & community health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Learning to be More Positive About FIT.The American journal of gastroenterology · 2018
    Article
  6. Article
  7. Which Fecal Immunochemical Test Should I Choose?Journal of primary care & community health · 2017
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jeanette M DalyThe University of Iowa, Iowa City, IA, USA.
Camden P Bay
Barcey T Levy

Funding

Comparative effectiveness of FIT vs. colonoscopy for colon cancer screeningRC1CA144907 · NCI · UNIVERSITY OF IOWA · PI LEVY, BARCEY THURSTON · 2009 to 2010
$782k
NCI NIH HHS 1RC1CA144907NCI NIH HHS RC1 CA144907
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) screening reduces the mortality due to CRC. It is important for health care providers to be aware of the variation in the products available for CRC screening. PURPOSE: The purpose of this study was to summarize the accuracy of results of individual fecal immunochemical test (FIT) products across pathology proficiency testing programs.

methodsSecondary data analysis of proficiency testing programs' FIT results.

resultsFour of 7 proficiency testing program's FIT evaluations were obtained for a 2-year period. Fourteen unique FIT brands were evaluated by at least 1 of the 4 proficiency testing programs. Five of the products performed similarly with sensitivities ranging from 98.1% to 98.8% and specificities from 98.1% to 99.6%. Ninety-three percent of the FIT tests completed were manual Clinical Laboratory Improvement Amendments-waived FITs.

conclusionsAbout two thirds of the commonly used FIT products performed acceptably on spiked samples of human hemoglobin. However, some had low sensitivity and specificity and probably should not be used for population-based or other screening. Further investigation to determine appropriate, reliable products for fecal occult blood testing is warranted.

Indexed as

Occult BloodColorectal NeoplasmsEarly Detection of CancerFecesHemoglobinsHumansImmunochemistryMass ScreeningReproducibility of ResultsSensitivity and SpecificityHemoglobinscolorectal cancer screeningfecal immunochemical test (FIT)fecal occult blood test (FOBT)proficiency testing programs

Identifiers

PMID23799674
PMCPMC3879722

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.