ArticleEnvironmental health perspectives2013
Phthalate exposure and allergy in the U.S. population: results from NHANES 2005-2006.
Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.
- Maternal Phthalate Exposure and Allergic Diseases in Children: A Meta-Analysis and Network Toxicology.International journal of molecular sciences · 2025Pooled it
- Untargeted metabolomic profiling of childhood asthma: An exploratory analysis of anthropogenic chemicals and the serum metabolome.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Exploring global research trends in sublingual immunotherapy of allergic rhinitis: a comprehensive bibliometric analysis.Immunotherapy · 2026Article
- Personal care product use and risk of adult-onset asthma: Prospective cohort analyses of U.S. Women from the Sister Study.Environment international · 2025Article
- Association between phthalate exposure and rash eczema disease: based on NHANES 2005-2006.Archives of dermatological research · 2025Article
- The association between environmental endocrine-disrupting chemicals and allergic disorders in children: A comprehensive systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Review
- Assessment of Phthalate Esters and Physiological Biomarkers in Bottlenose Dolphins (Animals : an open access journal from MDPI · 2024Article
- Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures.Heliyon · 2024Review
- Article
- Responses of peritubular macrophages and the testis transcriptome profiles of peripubertal and adult rodents exposed to an acute dose of MEHP.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- The effect of apigenin, an aryl hydrocarbon receptor antagonist, in Phthalate-Exacerbated eosinophilic asthma model.Journal of cellular and molecular medicine · 2023Article
- A cross sectional pilot study to assess the role of phthalates on respiratory morbidity among patients with chronic obstructive pulmonary disease.Environmental research · 2023Article
- Blood trihalomethane concentrations and allergic sensitization: A nationwide cross-sectional study.The Science of the total environment · 2023Article
- Mycotoxins fromMycology · 2023Article
- Phthalate Metabolites in Urine of Chinese Children and Their Association with Asthma and Allergic Symptoms.International journal of environmental research and public health · 2022Article
- Phthalate biomarkers and associations with respiratory symptoms and healthcare utilization among low-income urban children with asthma.Environmental research · 2022Article
- Expanded assessment of xenobiotic associations with antinuclear antibodies in the United States, 1988-2012.Environment international · 2022Article
- Phthalate Exposure and Oxidative/Nitrosative Stress in Childhood Asthma: A Nested Case-Control Study with Propensity Score Matching.Biomedicines · 2022Article
- Diagnostic Fragmentation Pathways for Identification of Phthalate Metabolites in Nontargeted Analysis Studies.Journal of the American Society for Mass Spectrometry · 2022Article
- The Role of Di(2-Ethylhexyl) Phthalate as an Exacerbating Factor in Chronic Spontaneous Urticaria.Allergy, asthma & immunology research · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundEnvironmental exposures to phthalates, particularly high-molecular-weight (HMW) phthalates, are suspected to contribute to allergy.
objectiveWe assessed whether phthalate metabolites are associated with allergic symptoms and sensitization in a large nationally representative sample.
methodsWe used data on urinary phthalate metabolites and allergic symptoms (hay fever, rhinitis, allergy, wheeze, asthma) and sensitization from participants ≥ 6 years of age in the National Health and Nutrition Examination Survey (NHANES) 2005-2006. Allergen sensitization was defined as a positive response to at least one of 19 specific IgE antigens (≥ 0.35 kU/L). Odds ratios (ORs) per one log10 unit change in phthalate concentration were estimated using logistic regression adjusting for age, race, body mass index, gender, creatinine, and cotinine. Separate analyses were conducted for children (6-17 years of age) and adults.
resultsThe HMW phthalate metabolite monobenzyl phthalate (MBzP) was the only metabolite positively associated with current allergic symptoms in adults (wheeze, asthma, hay fever, and rhinitis). Mono-(3-carboxypropyl) phthalate and the sum of diethylhexyl phthalate metabolites (both representing HMW phthalate exposures) were positively associated with allergic sensitization in adults. Conversely, in children, HMW phthalate metabolites were inversely associated with asthma and hay fever. Of the low-molecular-weight phthalate metabolites, monoethyl phthalate was inversely associated with allergic sensitization in adults (OR = 0.79; 95% CI: 0.70, 0.90).
conclusionIn this cross-sectional analysis of a nationally representative sample, HMW phthalate metabolites, particularly MBzP, were positively associated with allergic symptoms and sensitization in adults, but there was no strong evidence for associations between phthalates and allergy in children 6-17 years of age.
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