ReviewWiley interdisciplinary reviews. Developmental biology
Control of adult stem cells in vivo by a dynamic physiological environment: diet-dependent systemic factors in Drosophila and beyond.
Review in Wiley interdisciplinary reviews. Developmental biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Starve-Feed Cycles Direct Quiescence to Proliferation Transitions inbioRxiv : the preprint server for biology · 2026Article
- Estrogen-related receptor is required in adult Drosophila females for germline stem cell maintenance.Developmental biology · 2025Article
- Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary.Biology open · 2023Article
- Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila.G3 (Bethesda, Md.) · 2022Article
- Repeated loss of variation in insect ovary morphology highlights the role of development in life-history evolution.Proceedings. Biological sciences · 2021Article
- CentTracker: a trainable, machine-learning-based tool for large-scale analyses ofMolecular biology of the cell · 2021Article
- Nuclear receptors linking physiology and germline stem cells in Drosophila.Vitamins and hormones · 2021Review
- Biology of theGenetics · 2019Review
- Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila.Developmental biology · 2019Article
- Transcriptomic analysis reveals differences in the regulation of amino acid metabolism in asexual and sexual planarians.Scientific reports · 2019Article
- High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow.Nature communications · 2019Article
- Insulin signaling acts in adult adipocytes via GSK-3β and independently of FOXO to control Drosophila female germline stem cell numbers.Developmental biology · 2018Article
- Article
- Adipocyte Metabolic Pathways Regulated by Diet Control the Female Germline Stem Cell Lineage inGenetics · 2017Article
- Commensal bacteria and essential amino acids control food choice behavior and reproduction.PLoS biology · 2017Article
- Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from theCurrent stem cell reports · 2017Article
- RNAi-Based Techniques for the Analysis of Gene Function in Drosophila Germline Stem Cells.Methods in molecular biology (Clifton, N.J.) · 2017Article
- A visual screen for diet-regulated proteins in the Drosophila ovary using GFP protein trap lines.Gene expression patterns : GEP · 2017Article
- AMP-activated protein kinase has diet-dependent and -independent roles in Drosophila oogenesis.Developmental biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adult stem cells are inextricably linked to whole-body physiology and nutrient availability through complex systemic signaling networks. A full understanding of how stem cells sense and respond to dietary fluctuations will require identifying key systemic mediators, as well as elucidating how they are regulated and integrated with local and intrinsic factors across multiple tissues. Studies focused on the Drosophila germline have generated valuable insights into how stem cells are controlled by diet-dependent pathways, and increasing evidence suggests that diverse adult stem cell populations respond to nutrients through similar mechanisms. Systemic signals, including nutrients themselves and diet-regulated hormones such as Insulin/Insulin-like growth factor or steroid hormones, can directly or indirectly affect stem cell behavior by modifying local cell-cell communication or intrinsic factors. The physiological regulation of stem cells in response to nutritional status not only is a fascinating biological problem, but also has clinical implications, as research in this field holds the key to noninvasive approaches for manipulating stem cells in vivo. In addition, given the known associations between diet, stem cells, and cancer risk, this research may inspire novel anticancer therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.