ArticleInternational journal of molecular sciences2013
Diagnosis of desmoplastic reaction by immunohistochemical analysis, in biopsy specimens of early colorectal carcinomas, is efficacious in estimating the depth of invasion.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Prognostic value of desmoplastic stromal reaction, tumor budding and tumor-stroma ratio in stage II colorectal cancer.Journal of gastrointestinal oncology · 2022Article
- Desmoplastic Reaction, Immune Cell Response, and Prognosis in Colorectal Cancer.Frontiers in immunology · 2022Article
- A new practical classification of desmoplastic reaction in endoscopic forceps biopsy of colorectal cancer.Histology and histopathology · 2021Article
- Can transrectal ultrasound-guided core needle biopsy serve as an accurate diagnostic tool for rectal lesions?Annals of translational medicine · 2020Article
- Diminutive intramucosal invasive (Tis) sigmoid colon carcinoma.Clinical journal of gastroenterology · 2018Article
- Mechanisms underlying cancer growth and apoptosis by DEK overexpression in colorectal cancer.PloS one · 2014Article
- Depth of submucosal invasion vs. Haggitt level as prognostic predictors of pedunculated‑type early‑stage colorectal cancer removed by endoscopic resection.Medicine internationalArticle
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of our study was to evaluate the diagnosis of desmoplastic reaction (DR) by immunostaining for α-smooth muscle actin (αSMA) and desmin, for predicting the depth of submucosal invasion in biopsy specimens of early colorectal carcinomas (CRCs). Thirty-eight cases of non-pedunculated early CRCs were included in this study. Positive for DR was defined as αSMA-positive and desmin-negative stroma in the CRC. The depth of submucosal invasion was measured in endoscopically or surgically resected specimens and the lesions were subsequently divided into two groups: Group A (carcinoma in situ/intramucosal carcinoma and submucosal invasive carcinoma with a depth <1000 μm) and Group B (submucosal invasion with a depth ≥1000 μm). Twenty-one cases were DR-positive and 17 were DR-negative. No statistical significance was found between the DR with regard to tumor size, location and histological type. All DR-positive cases belonged to Group B whereas 14 (82.4%) DR-negative lesions belonged to Group A (p < 0.001). The sensitivity, specificity, positive and negative predictive values and accuracy of DR positivity for diagnosis of Group B were 87.5%, 100%, 100%, 82.4% and 92.1%, respectively. Conclusively, detection of DR in biopsy specimens with ancillary immunohistochemistry (αSMA/desmin) would help in preoperative diagnosis for the depth of submucosal invasion of early CRC.
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