ArticlePloS one2013
A comparative analysis of transcription factor expression during metazoan embryonic development.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Developmental and tissue expression breadth define distinct but overlapping classes of housekeeping genes.PLoS computational biology · 2026Article
- A cellular basis for the hourglass pattern in vertebrate embryogenesis.Nature communications · 2026Review
- A transcriptomic examination of encased rotifer embryos reveals the developmental trajectory leading to long-term dormancy; are they "animal seeds"?BMC genomics · 2024Article
- The hourglass model of evolutionary conservation during embryogenesis extends to developmental enhancers with signatures of positive selection.Genome research · 2021Article
- Genome-Wide Identification, Comparison, and Expression Analysis of Transcription Factors in AscidianInternational journal of molecular sciences · 2021Article
- Inter-embryo gene expression variability recapitulates the hourglass pattern of evo-devo.BMC biology · 2020Article
- Quantifying the extent of morphological homoplasy: A phylogenetic analysis of 490 characters inEvolution letters · 2019Article
- Embryonic lethality is not sufficient to explain hourglass-like conservation of vertebrate embryos.EvoDevo · 2018Article
- Article
- Gap Gene Regulatory Dynamics Evolve along a Genotype Network.Molecular biology and evolution · 2016Article
- Convergent occurrence of the developmental hourglass in plant and animal embryogenesis?Annals of botany · 2016Review
- Ancestral role of Pax2/5/8 in molluscan brain and multimodal sensory system development.BMC evolutionary biology · 2015Article
- A pipeline for the systematic identification of non-redundant full-ORF cDNAs for polymorphic and evolutionary divergent genomes: Application to the ascidian Ciona intestinalis.Developmental biology · 2015Article
- Evidence for active maintenance of phylotranscriptomic hourglass patterns in animal and plant embryogenesis.Molecular biology and evolution · 2015Article
- Deep vertebrate roots for mammalian zinc finger transcription factor subfamilies.Genome biology and evolution · 2014Article
- An explanatory evo-devo model for the developmental hourglass.F1000Research · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During embryonic development, a complex organism is formed from a single starting cell. These processes of growth and differentiation are driven by large transcriptional changes, which are following the expression and activity of transcription factors (TFs). This study sought to compare TF expression during embryonic development in a diverse group of metazoan animals: representatives of vertebrates (Danio rerio, Xenopus tropicalis), a chordate (Ciona intestinalis) and invertebrate phyla such as insects (Drosophila melanogaster, Anopheles gambiae) and nematodes (Caenorhabditis elegans) were sampled, The different species showed overall very similar TF expression patterns, with TF expression increasing during the initial stages of development. C2H2 zinc finger TFs were over-represented and Homeobox TFs were under-represented in the early stages in all species. We further clustered TFs for each species based on their quantitative temporal expression profiles. This showed very similar TF expression trends in development in vertebrate and insect species. However, analysis of the expression of orthologous pairs between more closely related species showed that expression of most individual TFs is not conserved, following the general model of duplication and diversification. The degree of similarity between TF expression between Xenopus tropicalis and Danio rerio followed the hourglass model, with the greatest similarity occuring during the early tailbud stage in Xenopus tropicalis and the late segmentation stage in Danio rerio. However, for Drosophila melanogaster and Anopheles gambiae there were two periods of high TF transcriptome similarity, one during the Arthropod phylotypic stage at 8-10 hours into Drosophila development and the other later at 16-18 hours into Drosophila development.
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