ArticlePloS one2013
Genetic polymorphism in PDE4D gene and risk of ischemic stroke in Chinese population: a meta-analysis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- The SNP rs1883832 in CD40 gene and risk of atherosclerosis in Chinese population: a meta-analysis.PloS one · 2014Pooled it
- Genetics of ischemic stroke functional outcome.Journal of neurology · 2024Review
- Associations between SNP83 of phosphodiesterase 4D gene and carotid atherosclerosis in a southern Chinese Han population: a case-control study.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Article
- Association between PDE4D polymorphism and ischemic stroke in young population.Saudi journal of biological sciences · 2019Article
- Monogenic, Polygenic, and MicroRNA Markers for Ischemic Stroke.Molecular neurobiology · 2019Review
- A meta-analysis of PDE-gene polymorphism and cerebral infarction risk.Experimental and therapeutic medicine · 2017Article
- Phosphodiesterase 4D polymorphisms associate with the short-term outcome in ischemic stroke.Scientific reports · 2017Article
- Effects of PDE4 pathway inhibition in rat experimental stroke.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2014Article
- Associations of genetic polymorphisms of SAA1 with cerebral infarction.Lipids in health and disease · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStroke is the second most common cause of death and major cause of disability worldwide. The SNP 83 in PDE4D gene has been suggested as a risk factor in ischemic stroke, but direct evidence from genetic association studies remains inconclusive even in Chinese population.
methodsMeta-analysis of case-control studies on the relationship between SNP 83 in PDE4D gene and susceptibility to ischemic stroke in Chinese population published domestically and abroad from January 2003 to September 2012.
results9 case-control studies were selected. Meta-analysis results showed that the significant association between SNP 83 and ischemic stroke was found under the dominant model (OR = 1.34, 95% CI: 1.20-1.49) and recessive model (OR = 1.45, 95% CI: 1.19-1.76) in Chinese population. In subgroup meta-analysis, SNP 83 and atherothrombotic stroke, rather than lacunar stroke, showed the significant association under the dominant model (OR = 1.69, 95% CI: 1.41-2.01) and recessive model (OR = 1.47, 95% CI: 1.04-2.06).
conclusionsThe results suggest that SNP 83 in PDE4D gene is significantly associated with susceptibility to ischemic stroke in Chinese population.
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