ArticlePloS one2013
Whole-brain functional connectivity identification of functional dyspepsia.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Second Asian Consensus Report on Functional Dyspepsia (2025): Updated Recommendations.Journal of gastroenterology and hepatology · 2026Pooled it
- The participation of basolateral amygdala in the efficacy of acupuncture with deqi treating for functional dyspepsia.Brain imaging and behavior · 2021Trial
- Central control of gastrointestinal functions in health and disease.Physiological reviews · 2026Review
- Topological Reorganization and Resting-State Functional Connectivity in Functional Dyspepsia: Associations of Symptoms with Peripheral Cytokine Levels and Amygdala Nodal Centrality.Molecular neurobiology · 2025Article
- Resting functional magnetic resonance images of the brain in functional gastrointestinal diseases: a concise review of the literature.Gastroenterology and hepatology from bed to bench · 2025Review
- Medical image segmentation based on simulated annealing and opposition-based learning island algorithm.PloS one · 2024Article
- Electroacupuncture in the treatment of IBS in rats: investigation of the mechanisms of CRHJournal of neurophysiology · 2023Article
- Differential responses from the left postcentral gyrus, right middle frontal gyrus, and precuneus to meal ingestion in patients with functional dyspepsia.Frontiers in psychiatry · 2023Article
- Abnormal rich club organization in end-stage renal disease patients before dialysis initiation and undergoing maintenance hemodialysis.BMC nephrology · 2020Article
- Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities.Nature reviews. Neurology · 2020Review
- Altered Functional Connectivity of the Amygdala and Sex Differences in Functional Dyspepsia.Clinical and translational gastroenterology · 2019Article
- Understanding Neurogastroenterology From Neuroimaging Perspective: A Comprehensive Review of Functional and Structural Brain Imaging in Functional Gastrointestinal Disorders.Journal of neurogastroenterology and motility · 2018Review
- How to Perform and Interpret Functional Magnetic Resonance Imaging Studies in Functional Gastrointestinal Disorders.Journal of neurogastroenterology and motility · 2017Review
- Topological Alterations of the Intrinsic Brain Network in Patients with Functional Dyspepsia.Journal of neurogastroenterology and motility · 2016Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent neuroimaging studies have shown local brain aberrations in functional dyspepsia (FD) patients, yet little attention has been paid to the whole-brain resting-state functional network abnormalities. The purpose of this study was to investigate whether FD disrupts the patterns of whole-brain networks and the abnormal functional connectivity could reflect the severity of the disease. The dysfunctional interactions between brain regions at rest were investigated in FD patients as compared with 40 age- and gender- matched healthy controls. Multivariate pattern analysis was used to evaluate the discriminative power of our results for classifying patients from controls. In our findings, the abnormal brain functional connections were mainly situated within or across the limbic/paralimbic system, the prefrontal cortex, the tempo-parietal areas and the visual cortex. About 96% of the subjects among the original dataset were correctly classified by a leave one-out cross-validation approach, and 88% accuracy was also validated in a replication dataset. The classification features were significantly associated with the patients' dyspepsia symptoms, the self-rating depression scale and self-rating anxiety scale, but it was not correlated with duration of FD patients (p>0.05). Our results may indicate the effectiveness of the altered brain functional connections reflecting the disease pathophysiology underling FD. These dysfunctional connections may be the epiphenomena or causative agents of FD, which may be affected by clinical severity and its related emotional dimension of the disease rather than the clinical course.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.