ArticlePloS one2013
COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Association Between Polymorphisms of DRD2, COMT, DBH, and MAO-A Genes and Migraine Susceptibility: A Meta-Analysis.Medicine · 2015Pooled it
- Effects of Ginkgo biloba extract EGb 761® on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity in elderly adults with subjective memory impairment - a randomized double-blind placebo-controlled trial.Human psychopharmacology · 2016Trial
- Autonomic Nervous System Responses to Viewing Green and Built Settings: Differentiating Between Sympathetic and Parasympathetic Activity.International journal of environmental research and public health · 2015Trial
- The Interaction of Polygenic Susceptibility to Stress and Childhood Adversity Dimensions Predicts Longitudinal Trajectories of Stress-Sensitivity.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- The Biology of Stress Intolerance in Patients with Chronic Pain-State of the Art and Future Directions.Journal of clinical medicine · 2023Review
- Role of COMT V158M Polymorphism in the Development of Dystonia after Administration of Antipsychotic Drugs.Brain sciences · 2021Article
- First Demonstration of Double Dissociation between COMT-Met158 and COMT-Val158 Cognitive Performance When Stressed and When Calmer.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Affective and psychotic reactivity to daily-life stress in adults with 22q11DS: a study using the experience sampling method.Journal of neurodevelopmental disorders · 2020Article
- Lower [Psychological medicine · 2020Article
- Early-Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes.Alcoholism, clinical and experimental research · 2019Article
- Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition.PloS one · 2018Article
- New Repeat Polymorphism in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The effect ofBrain and behavior · 2017Article
- The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.Biological psychiatry · 2017Review
- Mechanisms of Neurotoxic Symptoms as a Result of Breast Cancer and Its Treatment: Considerations on the Contribution of Stress, Inflammation, and Cellular Bioenergetics.Current breast cancer reports · 2017Review
- Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers.Translational psychiatry · 2016Article
- Article
- COMT Diplotype Amplifies Effect of Stress on Risk of Temporomandibular Pain.Journal of dental research · 2015Article
- No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder.Translational psychiatry · 2015Article
- Modulation of the COMT Val(158)Met polymorphism on resting-state EEG power.Frontiers in human neuroscience · 2015Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catechol-O-methyltransferase (COMT) plays an essential role in degradation of extracellular dopamine in prefrontal regions of the brain. Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. We aimed to investigate the effect of variations in COMT genotype on in vivo measures of stress-induced prefrontal cortex (PFC) dopaminergic processing and subjective stress responses. A combined sample of healthy controls and healthy first-degree relatives of psychosis patients (n = 26) were subjected to an [(18)F]fallypride Positron Emission Tomography scan. Psychosocial stress during the scan was induced using the Montreal Imaging Stress Task and subjective stress was assessed every 12 minutes. Parametric t-maps, generated using the linear extension of the simplified reference region model, revealed an effect of COMT genotype on the spatial extent of [(18)F]fallypride displacement. Detected effects of exposure to psychosocial stress were unilateral and remained restricted to the left superior and right inferior frontal gyrus, with Met-hetero- and homozygotes showing less [(18)F]fallypride displacement than Val-homozygotes. Additionally, Met-hetero- and homozygotes experienced larger subjective stress responses than Val-homozygotes. The direction of the effects remained the same when the data was analyzed separately for controls and first-degree relatives. The human stress response may be mediated in part by COMT-dependent dopaminergic PFC activity, providing speculation for the neurobiology underlying COMT-dependent differences in human behaviour following stress. Implications of these results for stress-related psychopathology and models of dopaminergic functioning are discussed.
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