ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2012
Ameliorative effects of metformin on renal histologic and biochemical alterations of gentamicin-induced renal toxicity in Wistar rats.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 111 citations in OpenAlex.
- Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report.Journal of medical case reports · 2023Article
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- The Current and Potential Therapeutic Use of Metformin-The Good Old Drug.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Chronic kidney disease in pregnant mothers affects maternal and fetal disposition of mercury.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
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- The Role of Mitochondria in Drug-Induced Kidney Injury.Frontiers in physiology · 2020Review
- Can crocin play a preventive role in Wistar rats with carbon tetrachloride-induced nephrotoxicity?Iranian journal of basic medical sciences · 2018Article
- Protective effect of hydroalcoholic extract of Pistacia vera against gentamicin-induced nephrotoxicity in rats.Renal failure · 2017Article
- Listeriosis Phytotherapy: A Review Study on the Effectiveness of Iranian Medicinal Plants in Treatment of Listeriosis.Journal of evidence-based complementary & alternative medicine · 2017Review
- Impact ofJournal of nephropharmacology · 2017Article
- The protective effect of hydro-alcoholic extract of mangrove (Journal of nephropathology · 2016Article
- Compensatory renal hypertrophy and the handling of an acute nephrotoxicant in a model of aging.Experimental gerontology · 2016Article
- An ethno-medicinal study of medicinal plants used for the treatment of diabetes.Journal of nephropathology · 2016Article
- Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences.Jundishapur journal of microbiology · 2015Review
- Article
- Antioxidant plants and diabetes mellitus.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Review
- Antioxidant Activity and Teratogenicity Evaluation of Lawsonia Inermis in BALB/c Mice.Journal of clinical and diagnostic research : JCDR · 2015Article
- Novel Hg2+-induced nephropathy in rats and mice lacking Mrp2: evidence of axial heterogeneity in the handling of Hg2+ along the proximal tubule.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Metformin and diabetic kidney disease: a mini-review on recent findings.Iranian journal of pediatrics · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to test the potential properties of metformin (MF) to protect the kidney from gentamicin (GM)-induced renal toxicity. MATERIALS AND
methodsIn this preclinical study, 50 male Wistar rats were randomly divided into five groups of 10 rats in each. In the first group (group I), they were kept in the same condition as others without receiving drugs for 10 days. In group II, the rats were injected intraperitoneally with 100 mg/kg/day of GM for 10 consecutive days. Group III rats received 100 mg/kg/day MF orally for 10 days. In group IV, the rats received GM (100 mg/kg; intraperitoneally) for 10 days and 100 mg/kg/day MF orally for the next 10 days. In the last group (group V), the rats received a combination of GM 100 mg/kg/day intraperitoneally and MF 100 mg/kg/day orally for 10 days simultaneously. Serum blood urea nitrogen (BUN) and creatinine (Cr) values were measured and renal tissues of the animals were processed for light microscope examination.
resultsThe levels of BUN in groups II, IV, and V, and also the serum level of Cr in groups II and V were increased significantly after the experiment. Furthermore, post-treatment with MF or co-treatment with MF could prevent the elevation of serum BUN and Cr induced by GM and also attenuates the damage score (P < 0.05).
conclusionsMF may prevent or ameliorate GM-induced acute renal failure, and therefore it might be beneficial in patients under treatment with this medicine.
Indexed as
Identifiers
23798920PMC3685776W1488598324What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.