ArticlePharmacognosy research2013
Anti-arthritic activity of ethanolic extract of Tridax procumbens (Linn.) in Sprague Dawley rats.
Article in Pharmacognosy research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Isolation, purification and characterization of quercetin from3 Biotech · 2023Article
- Article
- A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases.Frontiers in pharmacology · 2020Review
- Antiarthritic activity of a polyherbal formulation against Freund's complete adjuvant induced arthritis in Female Wistar rats.Journal of basic and clinical pharmacy · 2015Article
- Antidiabetic activity of polyherbal formulation in streptozotocin - nicotinamide induced diabetic wistar rats.Journal of traditional and complementary medicine · 2014Article
- Antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Linn.) in streptozotocin-induced diabetic rats.Journal of basic and clinical pharmacy · 2013Article
- Anti-arthritic potential of ethanol and aqueous extracts of stem bark of Cleistopholis patens on complete Freund's adjuvant-induced rheumatoid arthritis in rats.Journal of Ayurveda and integrative medicineArticle
- Comparative Antioxidant and Anti-gout Activities ofAvicenna journal of medical biotechnologyArticle
- Anti-inflammatory and antiarthritic activity of UNIM-301 (a polyherbal unani formulation) in Wistar rats.Pharmacognosy researchArticle
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the anti-arthritic effect of whole plant ethanolic extract of Tridax procumbens (Asteraceae) in female Sprague Dawley (SD) rats using the Freund's Complete Adjuvant (FCA) model. MATERIALS AND
methodsThe plant was collected from different regions of Madurai District, Tamil Nadu, and the phytoconstituents were identified through chemical tests. Ethanol (95%) was used to obtain the whole plant extraction through Soxhlet extractor. Female SD rats were used for anti-arthritic screening. Arthritis was induced using FCA, and the anti-arthritic effect of the ethanolic extract of T. procumbens was studied at doses of 250 and 500 mg/kg. The effects were compared with those of indomethacin (10 mg/kg). At the end of the study, the liver enzyme levels were determined and a radiological examination was carried out.
resultThe preliminary phytochemical analysis of the ethanolic extract of T. procumbens indicated the presence of alkaloids, tannins, flavonoids and saponins. T. procumbens at 250 and 500 mg/kg significantly inhibited the FCA-induced arthritis in the rats. This was manifested by as a decrease in the paw volume. The arthritic control animals exhibited a significant decrease in body weight compared with control animals without arthritis. T. procumbens animals showed dose dependent reduction in decrees in body weight and arthritis. At the same time, T. procumbens significantly altered the biochemical and haematological changes induced by FCA (P < 0.05). The anti-arthritic effect of T. procumbens was comparable with that of indomethacin.
conclusionThe whole plant extract of T. procumbens showed significant anti-arthritic activity against FCA-induced arthritis in female SD rats.
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