ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2013
Preventive chemotherapy as a strategy for elimination of neglected tropical parasitic diseases: endgame challenges.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 8 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Risk factors of lymphatic filariasis in Asia: a systematic review.BMC infectious diseases · 2025Pooled it
- Global prevalence of intestinal parasites in cancer patients: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Efficacy of Albendazole and Mebendazole Against Soil Transmitted Infections among Pre-School and School Age Children: A Systematic Review and Meta-Analysis.Journal of epidemiology and global health · 2024Pooled it
- Prevalence of intestinal parasitic infections in Brazil: a systematic review.Revista da Sociedade Brasileira de Medicina Tropical · 2021Pooled it
- A systematic review of factors that shape implementation of mass drug administration for lymphatic filariasis in sub-Saharan Africa.BMC public health · 2017Pooled it
- Compliance with anthelmintic treatment in the neglected tropical diseases control programmes: a systematic review.Parasites & vectors · 2016Pooled it
- The roles of water, sanitation and hygiene in reducing schistosomiasis: a review.Parasites & vectors · 2015Pooled it
- The relationship between water, sanitation and schistosomiasis: a systematic review and meta-analysis.PLoS neglected tropical diseases · 2014Pooled it
- Spatial distribution of urogenital schistosomiasis in school-aged children in Togo: an oversampling survey in three districts in 2022.Parasites & vectors · 2026Article
- Integration of deworming into primary healthcare in Western Kenya: a quasi-experimental evaluation.Frontiers in public health · 2026Article
- Psychological health and motivational factors of health workers and community volunteers in preventive chemotherapy programs for neglected tropical diseases control in Ekiti State, Nigeria.BMC public health · 2025Article
- Current state and future directions of interventions for neglected tropical diseases.Nature human behaviour · 2025Review
- Usability, acceptability, and cost of the SD BIOLINE Ov16 rapid diagnostic test for onchocerciasis surveillance in endemic communities in the middle belt of Ghana.PLoS neglected tropical diseases · 2025Article
- The Impact of a Community Pharmacy-Led Deworming-Related Counselling Service: An Interventional Study in a Low-to-Middle Income Country.Tropical medicine and infectious disease · 2025Article
- Considerations and expectations for the administration of dispersible arpraziquantel to young children: a landscape analysis.International health · 2025Article
- Current perspectives in the epidemiology and control of lymphatic filariasis.Clinical microbiology reviews · 2025Review
- Schistosomiasis Interventions in Africa: Assessment and Systematic Review.Journal of parasitology research · 2025Review
- Onchocerciasis in the Cameroon-Chad border area after more than 20 years of annual mass ivermectin distribution.Parasites & vectors · 2024Article
- Impact of conflict on the elimination targets of lymphatic filariasis, schistosomiasis and soil-transmitted helminths in Cabo Delgado province, Mozambique.PLoS neglected tropical diseases · 2024Article
- Effects of Iron-Fortified Foods on the Nutritional Status of Children Residing in Regions Vulnerable to Parasitic Diseases: A Systematic Review.Preventive nutrition and food science · 2024Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Global efforts to address neglected tropical diseases (NTDs) were stimulated in January 2012 by the London declaration at which 22 partners, including the Bill & Melinda Gates Foundation, World Bank, World Health Organization (WHO) and major pharmaceutical companies committed to sustaining and expanding NTD programmes to eliminate or eradicate 11 NTDs by 2020 to achieve the goals outlined in the recently published WHO road map. Here, we present the current context of preventive chemotherapy for some NTDs, and discuss the problems faced by programmes as they consider the 'endgame', such as difficulties of access to populations in post-conflict settings, limited human and financial resources, and the need to expand access to clean water and improved sanitation for schistosomiasis and soil-transmitted helminthiasis. In the case of onchocerciasis and lymphatic filariasis, ivermectin treatment carries a significant risk owing to serious adverse effects in some patients co-infected with the tropical eye worm Loa loa filariasis. We discuss the challenges of managing complex partnerships, and maintain advocacy messages for the continued support for elimination of these preventable diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.