ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2013
The final stages of the global eradication of poliomyelitis.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Equivalent schedules of intradermal fractional dose versus intramuscular full dose of inactivated polio vaccine for prevention of poliomyelitis.The Cochrane database of systematic reviews · 2019Pooled it
- A phase I, open label, clinical study to assess the safety and immunogenicity of indigenously developed liquid (DTwP-HepB-IPV-Hib) hexavalent combination vaccine in healthy toddlers aged 16-24 months.Human vaccines & immunotherapeutics · 2022Trial
- Differences in nasal immunoglobulin A responses to influenza vaccine strains after live attenuated influenza vaccine (LAIV) immunization in children.Clinical and experimental immunology · 2020Trial
- Neonatal vitamin A supplementation and immune responses to oral polio vaccine in Zimbabwean infants.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2019Trial
- The global threat of vaccine-preventable neurological diseases.Nature reviews. Neurology · 2026Review
- Links between infrastructure for human movement and early Ebola outbreak trajectories.Scientific reports · 2026Article
- Article
- Response to Vaccine-Derived Polioviruses Detected through Environmental Surveillance, Guatemala, 2019.Emerging infectious diseases · 2023Review
- Evaluation of acute flaccid paralysis surveillance system in the River Nile State - Northern Sudan, 2021.BMC public health · 2023Article
- Article
- Economic assessment of incorporating the hexavalent vaccine as part of the National Immunization Program of Peru.BMC health services research · 2022Article
- A genetic barcode of SARS-CoV-2 for monitoring global distribution of different clades during the COVID-19 pandemic.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020Article
- Policy responses and government science advice for the COVID 19 pandemic in the Philippines: January to April 2020.Progress in disaster science · 2020Article
- Review of poliovirus modeling performed from 2000 to 2019 to support global polio eradication.Expert review of vaccines · 2020Review
- Geneva Health Forum: The Forum of Innovative Practices in Global Health.International journal of environmental research and public health · 2020Article
- Development of a thermostable microneedle patch for polio vaccination.Drug delivery and translational research · 2019Article
- Acute flaccid paralysis (AFP) surveillance intensification for polio certification in Kaduna state, Nigeria: lessons learnt, 2015-2016.BMC public health · 2018Article
- Epidemiology of the silent polio outbreak in Rahat, Israel, based on modeling of environmental surveillance data.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Low Rates of Poliovirus Antibodies in Primary Immunodeficiency Patients on Regular Intravenous Immunoglobulin Treatment.Journal of clinical immunology · 2018Article
- Attitude and subjective wellbeing of non-compliant mothers to childhood oral polio vaccine supplemental immunization in Northern Nigeria.BMC public health · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The global incidence of poliomyelitis has dropped by more than 99 per cent since the governments of the world committed to eradication in 1988. One of the three serotypes of wild poliovirus has been eradicated and the remaining two serotypes are limited to just a small number of endemic regions. However, the Global Polio Eradication Initiative (GPEI) has faced a number of challenges in eradicating the last 1 per cent of wild-virus transmission. The polio endgame has also been complicated by the recognition that vaccination with the oral poliovirus vaccine (OPV) must eventually cease because of the risk of outbreaks of vaccine-derived polioviruses. I describe the major challenges to wild poliovirus eradication, focusing on the poor immunogenicity of OPV in lower-income countries, the inherent limitations to the sensitivity and specificity of surveillance, the international spread of poliovirus and resulting outbreaks, and the potential significance of waning intestinal immunity induced by OPV. I then focus on the challenges to eradicating all polioviruses, the problem of vaccine-derived polioviruses and the risk of wild-type or vaccine-derived poliovirus re-emergence after the cessation of oral vaccination. I document the role of research in the GPEI's response to these challenges and ultimately the feasibility of achieving a world without poliomyelitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.