ArticleThe Journal of biological chemistry2013
miR-200s contribute to interleukin-6 (IL-6)-induced insulin resistance in hepatocytes.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 66 citations in OpenAlex.
- Associations ofTherapeutic advances in gastroenterology · 2026Article
- Impact of Lipids on Insulin Resistance: Insights from Human and Animal Studies.Drug design, development and therapy · 2024Review
- Obesity and Clonal Hematopoiesis of Indeterminate Potential: Allies in Cardiovascular Diseases and Malignancies.Life (Basel, Switzerland) · 2023Review
- Urinary microRNA in Diabetic Kidney Disease: A Literature Review.Medicina (Kaunas, Lithuania) · 2023Review
- Article
- Metabolic imprinting induced by a high-sugar diet: effects on microRNA expression and insulin resistance in young rats.Molecular biology reports · 2022Article
- Adipokine Levels in Men with Coronary Atherosclerosis on the Background of Abdominal Obesity.Journal of personalized medicine · 2022Article
- Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2.JCI insight · 2022Article
- MiR-200c-3p Regulates DUSP1/MAPK Pathway in the Nonalcoholic Fatty Liver After Laparoscopic Sleeve Gastrectomy.Frontiers in endocrinology · 2022Article
- Akt: A Potential Drug Target for Metabolic Syndrome.Frontiers in physiology · 2022Review
- Mechanisms of Post-Pancreatitis Diabetes Mellitus and Cystic Fibrosis-Related Diabetes: A Review of Preclinical Studies.Frontiers in endocrinology · 2021Review
- Obesity and obesity-induced inflammatory disease contribute to atherosclerosis: a review of the pathophysiology and treatment of obesity.American journal of cardiovascular disease · 2021Review
- Role of miRNAs in the pathogenesis of T2DM, insulin secretion, insulin resistance, and β cell dysfunction: the story so far.Journal of physiology and biochemistry · 2020Review
- Article
- Molecular biomarkers in diabetes mellitus (DM).Medical journal of the Islamic Republic of Iran · 2020Review
- Epigenetic repression of miR-17 contributed to di(2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal muscle.Theranostics · 2020Article
- Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders.International journal of molecular sciences · 2019Review
- MicroRNA-200b and microRNA-200c are up-regulated in PCOS granulosa cell and inhibit KGN cell proliferation via targeting PTEN.Reproductive biology and endocrinology : RB&E · 2019Article
- MicroRNA-106b-5p promotes hepatocellular carcinoma development via modulating FOG2.OncoTargets and therapy · 2019Article
- Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA.International journal of molecular medicine · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By influencing the activity of the PI3K/AKT pathway, IL-6 acts as an important regulator of hepatic insulin resistance. miR-200s have been shown to control growth by regulating PI3K, but the role of miR-200s in the development of hepatic insulin resistance remains unclear. The present study showed that elevated serum concentration of IL-6 is associated with decreased levels of miR-200s, impaired activation of the AKT/glycogen synthase kinase (GSK) pathway, and reduced glycogenesis that occurred in the livers of db/db mice. As shown in the murine NCTC 1469 hepatocytes and the primary hepatocytes treated with 10 ng/ml IL-6 for 24 h and in 12-week-old male C57BL/6J mice injected with 16 μg/ml IL-6 by pumps for 7 days, IL-6 administration induced insulin resistance through down-regulation of miR-200s. Moreover, IL-6 treatment inhibited the phosphorylation of AKT and GSK and decreased the glycogenesis. The effects of IL-6 could be diminished by suppression of FOG2 expression. We concluded that IL-6 treatment may impair the activities of the PI3K/AKT/GSK pathway and inhibit the synthesis of glycogen, perhaps via down-regulating miR-200s while augmenting FOG2 expression.
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