ArticleOncotarget2013
Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer.
Article in Oncotarget, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- S100A8/A9 as a risk factor for breast cancer negatively regulated by DACH1.Biomarker research · 2023Article
- Retinal determination gene networks: from biological functions to therapeutic strategies.Biomarker research · 2023Review
- Effect of DACH1 on proliferation and invasion of laryngeal squamous cell carcinoma.Head & face medicine · 2018Article
- DACH1 inhibits glioma invasion and tumor growth via the Wnt/catenin pathway.OncoTargets and therapy · 2018Article
- DACH1 suppresses breast cancer as a negative regulator of CD44.Scientific reports · 2017Article
- Decreased DACH1 expression in glomerulopathy is associated with disease progression and severity.Oncotarget · 2016Article
- Circulating cell-free DNA-based epigenetic assay can detect early breast cancer.Breast cancer research : BCR · 2016Article
- The insights of Let-7 miRNAs in oncogenesis and stem cell potency.Journal of cellular and molecular medicine · 2016Review
- The retinal determination gene network: from developmental regulator to cancer therapeutic target.Oncotarget · 2016Review
- Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance.Cell reports · 2016Article
- Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells.Cancer gene therapy · 2016Article
- The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module.Cancer research · 2015Article
- DACH1 is a novel predictive and prognostic biomarker in hepatocellular carcinoma as a negative regulator of Wnt/β-catenin signaling.Oncotarget · 2015Article
- DACH1 inhibits lung adenocarcinoma invasion and tumor growth by repressing CXCL5 signaling.Oncotarget · 2015Article
- DACH1 inhibits SNAI1-mediated epithelial-mesenchymal transition and represses breast carcinoma metastasis.Oncogenesis · 2015Article
- Epigenetic silencing of DACH1 induces the invasion and metastasis of gastric cancer by activating TGF-β signalling.Journal of cellular and molecular medicine · 2014Article
- CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling.Oncotarget · 2014Article
- Article
- Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation.Cancer research · 2014Article
- Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
Breast cancer is a leading form of cancer in the world. The Drosophila Dac gene was cloned as an inhibitor of the hyperactive epidermal growth factor (EGFR), ellipse. Herein, endogenous DACH1 co-localized with p53 in a nuclear, extranucleolar compartment and bound to p53 in human breast cancer cell lines, p53 and DACH1 bound common genes in Chip-Seq. Full inhibition of breast cancer contact-independent growth by DACH1 required p53. The p53 breast cancer mutants R248Q and R273H, evaded DACH1 binding. DACH1 phosphorylation at serine residue (S439) inhibited p53 binding and phosphorylation at p53 amino-terminal sites (S15, S20) enhanced DACH1 binding. DACH1 binding to p53 was inhibited by NAD-dependent deacetylation via DACH1 K628. DACH1 repressed p21CIP1 and induced RAD51, an association found in basal breast cancer. DACH1 inhibits breast cancer cellular growth in an NAD and p53-dependent manner through direct protein-protein association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.